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Stepwise specification of lymphocyte developmental lineages

Rothenberg, Ellen V. (2000) Stepwise specification of lymphocyte developmental lineages. Current Opinion in Genetics and Development, 10 (4). pp. 370-379. ISSN 0959-437X. doi:10.1016/S0959-437X(00)00098-8.

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B and T lymphocytes differentiate from multipotent precursors through distinct specification and commitment steps. New findings on the unique role of Pax5 in B-lineage commitment, dichotomous action of Notch signaling in B versus T cell development, and the gene expression changes comprising T-lineage specification and commitment now illuminate this process.

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Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2000 Elsevier. Available online 14 July 2000; published 1 August 2000. Since the submission of this article, evidence has been published that Pax5 (BSAP) can interfere directly with transactivation functions of PU.1 [84]. This could play a role in repressing myelomonocytic genes during B-lineage commitment. The author is extremely grateful to David H Raulet (University of California, Berkeley), and to Hua Wang, Rochelle Diamond, Michele Anderson, F Chen, Gabriela Hernandez-Hoyos, and Janice Telfer in the author’s laboratory for permission to cite results prior to publication. The manuscript was also greatly improved by the critical reading and advice of Eric Davidson, Janice Telfer, and Michele Anderson. Finally, the conceptual framework of this review was enriched by valuable discussions with Michael Levine, Eric Davidson, and members of the Developmental Biology Colloquium at Caltech.
Subject Keywords:Development; Immunology; Genetics; B-cell development; T-cell development; Dendritic cell; Natural cell killer; Commitment; Transcription factor; Notch; Pax5; PU.1; bHLH
Issue or Number:4
Record Number:CaltechAUTHORS:20170206-114648134
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Official Citation:Ellen V Rothenberg, Stepwise specification of lymphocyte developmental lineages, Current Opinion in Genetics & Development, Volume 10, Issue 4, 1 August 2000, Pages 370-379, ISSN 0959-437X,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74081
Deposited By: Melissa Ray
Deposited On:06 Feb 2017 22:18
Last Modified:11 Nov 2021 05:24

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