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Death and transfiguration of cortical thymocytes: a reconsideration

Rothenberg, Ellen V. (1990) Death and transfiguration of cortical thymocytes: a reconsideration. Immunology Today, 11 (4). pp. 116-119. ISSN 0167-5699. doi:10.1016/0167-5699(90)90047-D.

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The fate of most cells in the mammalian thymus, namely CD4^+CD8^+ (double positive) cortical cells, is unknown. A fraction of the cells in this population serve as developmental intermediates, but the vast majority will die. In this article Ellen Rothenberg discusses how and when the cells are condemned or promoted to maturity, in the light of intriguing new data that suggests that they may be able to be rescued for longer than was previously thought.

Item Type:Article
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Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 1990 Published by Elsevier Ltd. Work in the author's laboratory was supported by grants from the USPHS-National Institutes of Health (Al 19752 and CA 39605), the Lucille B Markey Charitable Trust and the University of California University-Wide Task Force on AIDS. I am very grateful to Anthony Shields for bringing his findings to my attention, to Cynthia Guidos. Rochelle Diamond and Paul Boyer for their critical reading of this manuscript, to Cherrie Leighton for helping to prepare it for submission, and to Roland Scollay, Eric Jenkinson and John Owen for exceptionally stimulating and thought-provoking discussion of these issues.
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Lucille B. Markey Charitable TrustUNSPECIFIED
University of CaliforniaUNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20170206-130127645
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Official Citation:Ellen V Rothenberg, Death and transfiguration of cortical thymocytes: a reconsideration, Immunology Today, Volume 11, 1990, Pages 116-119, ISSN 0167-5699, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74085
Deposited By: Tony Diaz
Deposited On:06 Feb 2017 22:21
Last Modified:11 Nov 2021 05:24

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