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The long road to functional maturity for developing T cells

Rothenberg, Ellen V. (1989) The long road to functional maturity for developing T cells. Immunology Today, 10 (4). pp. 116-117. ISSN 0167-5699. doi:10.1016/0167-5699(89)90243-0.

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The past two years have clarified the role of the thymus as a filter for T cells with appropriate recognition specificities. What remains a knottier problem is the role of the thymus as an inductive microenvironment for changes in the regulation of genes involved in effector function - that is, making T cells into competent elements in immune defenses. It is still uncertain to what extent the functional role of a T cell - as an nterleukin 2 (IL-2)-producing helper, an IL-4-producing helper, or a killer expressing granzymes and perforin - is irreversibly determined by intiathymic events. Another, related question is whether the stimuli required by a cell to induce expression of any of its 'response' genes may also change in development, through maturation of specialized signal transduction pathways. If so, some differentiation events that profoundly affect the immunological role of T cells might be subtle and difficult to score.

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Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 1989 Elsevier Science Publishers Ltd.
Issue or Number:4
Record Number:CaltechAUTHORS:20170206-131122567
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Official Citation:Ellen V. Rothenberg, The long road to functional maturity for developing T cells, Immunology Today, Volume 10, Issue 4, April 1989, Pages 116-117, ISSN 0167-5699, (//
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74086
Deposited By: Tony Diaz
Deposited On:06 Feb 2017 22:04
Last Modified:11 Nov 2021 05:24

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