Warren, Luigi A. and Rothenberg, Ellen V. (2003) Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors. Current Opinion in Immunology, 15 (2). pp. 166-175. ISSN 0952-7915. https://resolver.caltech.edu/CaltechAUTHORS:20170206-133114488
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Abstract
During lymphopoiesis, precursor cells negotiate a complex regulatory space, defined by the levels of several competing and cross-regulating transcription factors, before arriving at stable states of commitment to the B-, T- and NK-specific developmental programs. Recent perturbation experiments provide evidence that this space has three major axes, corresponding to the PU.1 versus GATA-1 balance, the intensity of Notch signaling through the CSL pathway, and the ratio of E-box transcription factors to their Id protein antagonists.
| Item Type: | Article | |||||||||
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| Additional Information: | © 2003 Elsevier Science Ltd. This review comes from a themed issue on Lymphocyte development Edited by Ellen Robey and Mark Schlissel. | |||||||||
| Issue or Number: | 2 | |||||||||
| Record Number: | CaltechAUTHORS:20170206-133114488 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20170206-133114488 | |||||||||
| Official Citation: | Luigi A Warren, Ellen V Rothenberg, Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors, Current Opinion in Immunology, Volume 15, Issue 2, April 2003, Pages 166-175, ISSN 0952-7915, http://dx.doi.org/10.1016/S0952-7915(03)00011-6. (//www.sciencedirect.com/science/article/pii/S0952791503000116) | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 74087 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 06 Feb 2017 22:14 | |||||||||
| Last Modified: | 03 Oct 2019 16:34 |
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