Rothenberg, Ellen V. (1994) Signaling mechanisms in thymocyte selection. Current Opinion in Immunology, 6 (2). pp. 257-265. ISSN 0952-7915. https://resolver.caltech.edu/CaltechAUTHORS:20170206-135119164
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Abstract
The processes known as positive and negative selection that determine the fate of T and B cells depend on finely tuned interactions between the T-cell receptor complex, CD4 or CD8 co-receptors, and a peptide-MHC complex. New work indicates that the avidity of this interaction is critical in the determination of its outcome. The effects of these interactions on developing thymocytes are also a function of the unique activation properties with which thymocytes are programed just before they undergo selection.
| Item Type: | Article | |||||||||
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| Additional Information: | © 1994 Elsevier Ltd. | |||||||||
| Issue or Number: | 2 | |||||||||
| Record Number: | CaltechAUTHORS:20170206-135119164 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20170206-135119164 | |||||||||
| Official Citation: | Ellen V. Rothenberg, Signaling mechanisms in thymocyte selection, Current Opinion in Immunology, Volume 6, Issue 2, 1994, Pages 257-265, ISSN 0952-7915, http://dx.doi.org/10.1016/0952-7915(94)90099-X. (http://www.sciencedirect.com/science/article/pii/095279159490099X) | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 74090 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 06 Feb 2017 21:54 | |||||||||
| Last Modified: | 03 Oct 2019 16:34 |
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