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Signaling mechanisms in thymocyte selection

Rothenberg, Ellen V. (1994) Signaling mechanisms in thymocyte selection. Current Opinion in Immunology, 6 (2). pp. 257-265. ISSN 0952-7915.

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The processes known as positive and negative selection that determine the fate of T and B cells depend on finely tuned interactions between the T-cell receptor complex, CD4 or CD8 co-receptors, and a peptide-MHC complex. New work indicates that the avidity of this interaction is critical in the determination of its outcome. The effects of these interactions on developing thymocytes are also a function of the unique activation properties with which thymocytes are programed just before they undergo selection.

Item Type:Article
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Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 1994 Elsevier Ltd.
Issue or Number:2
Record Number:CaltechAUTHORS:20170206-135119164
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Official Citation:Ellen V. Rothenberg, Signaling mechanisms in thymocyte selection, Current Opinion in Immunology, Volume 6, Issue 2, 1994, Pages 257-265, ISSN 0952-7915, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74090
Deposited By: Tony Diaz
Deposited On:06 Feb 2017 21:54
Last Modified:03 Oct 2019 16:34

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