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Differentiation and cell division in the mammalian thymus

Rothenberg, Ellen and Lugo, James P. (1985) Differentiation and cell division in the mammalian thymus. Developmental Biology, 112 (1). pp. 1-17. ISSN 0012-1606. doi:10.1016/0012-1606(85)90114-9.

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The thymus is the primary differentiation site for T (thymus-derived) lymphocytes (Metcalf, 1966). Over the past 20 years, cell traffic to and from the thymus has been investigated, and the lymphocyte population of the thymus has been found to be composed of myriad phenotypically distinct subpopulations. Several recent reviews have treated these subjects in detail (e.g., Scollay and Shortman, 1983, 1985; Scollay et al, 1984a; Mathieson and Fowlkes, 1984; Fowlkes and Mathieson, 1985). This work has resulted in a wealth of information that allows T-cell development to be examined with high resolution. By this analysis, events in the thymus provide vivid and accessible examples of processes common to many developmental systems: specific homing and migration, formation of specific cell-cell contacts, mitogenesis, coordinate and noncoordinate gene activation, induction of gene rearrangements, and programmed cell death. In this review, current knowledge of the biology of the thymus serves as a framework to define the molecular events by which thymic precursor cells are endowed with the functional properties of mature T cells.

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Rothenberg, Ellen0000-0002-3901-347X
Additional Information:© 1985 Academic Press, Inc. Received 15 May 1985, Accepted 5 July 1985. We are grateful to B. J. Fowlkes, Cox Terhorst, Jayne Lesley, Robert Hyman, and Jan Trowbridge, for communicating results prior to publication; to Barry Caplan and Christine Kinnon for helpful discussions; to Rochelle Diamond Sailor and Santosh Krishnan for valuable contributions to the experiments; and to Eric Davidson and Lee Hoc for thoughtful criticism of the manuscript. Work in this laboratory was supported by USPHS Grants Al-19752, CA-34181, and CA-39505, and the cell sorting facility by CA-32911. JPL is a postdoctoral fellow of the Jane Coffin Childs Memorial Fund for Medical Research.
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Jane Coffin Childs Memorial Fund for Medical ResearchUNSPECIFIED
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Record Number:CaltechAUTHORS:20170206-145032179
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Official Citation:Ellen Rothenberg, James P. Lugo, Differentiation and cell division in the mammalian thymus, Developmental Biology, Volume 112, Issue 1, 1985, Pages 1-17, ISSN 0012-1606, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74098
Deposited By: Tony Diaz
Deposited On:06 Feb 2017 23:40
Last Modified:11 Nov 2021 05:24

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