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Molecular Indices of Functional Competence in Developing T Cells

Rothenberg, Ellen V. and McGuire, Kathleen L. and Boyer, Paul D. (1988) Molecular Indices of Functional Competence in Developing T Cells. Immunological Reviews, 104 (1). pp. 29-53. ISSN 0105-2896. https://resolver.caltech.edu/CaltechAUTHORS:20170206-155009290

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Abstract

The development of mature T cells in the thymus involves changes in the regulation of numerous genes. In some cases genes are turned on or off, while in others they acquire the ability to be expressed in response to appropriate stimuli. One set of genes whose expression is initiated in the thymus encodes the T-cell receptor chains. Although surface T-cell receptor expression is a prerequisite for mature responsiveness, it is not sufficient. Mature T cells must also be able to induce the expression of various batteries of unlinked genes in response to antigenic stimulation. These inducible genes include interleukin-2 (IL-2) and interferon-γ in some cells, interleukins-4 and -5 in others, perforins in still others, and the IL-2 receptor 55 kd chain, which must explain changes in the regulation of both constitutively expressed and inducible genes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/j.1600-065X.1988.tb00758.xDOIArticle
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-065X.1988.tb00758.x/abstractPublisherArticle
ORCID:
AuthorORCID
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 1988 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Issue or Number:1
Record Number:CaltechAUTHORS:20170206-155009290
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170206-155009290
Official Citation:Rothenberg, E. V., Mcguire, K. L. and Boyer, P. D. (1988), Molecular Indices of Functional Competence in Developing T Cells. Immunological Reviews, 104: 29–53. doi:10.1111/j.1600-065X.1988.tb00758.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74111
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Feb 2017 00:03
Last Modified:03 Oct 2019 16:34

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