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Progression of regulatory gene expression states in fetal and adult pro-T-cell development

David-Fung, Elizabeth-Sharon and Yui, Mary A. and Morales, Marissa and Wang, Hua and Taghon, Tom and Diamond, Rochelle A. and Rothenberg, Ellen V. (2006) Progression of regulatory gene expression states in fetal and adult pro-T-cell development. Immunological Reviews, 209 (1). pp. 212-236. ISSN 0105-2896. PMCID PMC4157939. https://resolver.caltech.edu/CaltechAUTHORS:20170207-082859641

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Abstract

Precursors entering the T-cell developmental pathway traverse a progression of states characterized by distinctive patterns of gene expression. Of particular interest are regulatory genes, which ultimately control the dwell time of cells in each state and establish the mechanisms that propel them forward to subsequent states. Under particular genetic and developmental circumstances, the transitions between these states occur with different timing, and environmental feedbacks may shift the steady-state accumulations of cells in each state. The fetal transit through pro-T-cell stages is faster than in the adult and subject to somewhat different genetic requirements. To explore causes of such variation, this review presents previously unpublished data on differentiation gene activation in pro-T cells of pre-T-cell receptor-deficient mutant mice and a quantitative comparison of the profiles of transcription factor gene expression in pro-T-cell subsets of fetal and adult wildtype mice. Against a background of consistent gene expression, several regulatory genes show marked differences between fetal and adult expression profiles, including those encoding two basic helix-loop-helix antagonist Id factors, the Ets family factor SpiB and the Notch target gene Deltex1. The results also reveal global differences in regulatory alterations triggered by the first T-cell receptor-dependent selection events in fetal and adult thymopoiesis.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/j.0105-2896.2006.00355.xDOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157939PubMed CentralArticle
ORCID:
AuthorORCID
Yui, Mary A.0000-0002-3136-2181
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2006 The Authors. Journal compilation © 2006 Blackwell Munksgaard. Issue online: 31 January 2006; Version of record online: 31 January 2006. The authors wish to thank Michele Anderson, Christopher Franco, and Rashmi Pant for valuable contributions to the foundations of this review when they were in the Rothenberg Laboratory, Satoko Adachi for genomic DNA-specific primers and advice, Stephanie Adams for outstanding multiparameter fluorescence-activated cell sorting, and Ruben Bayon and the staff of the Office for Laboratory Animal Research for expert care of numerous mutant mouse strains used in the research. We also thank Lee Rowen (Institute for Systems Biology, Seattle) for sequencing multiple pro-T cell cDNA clones. M. M. gratefully acknowledges funding from the Minority Under-graduate Research Fellowships Program at the California Institute of Technology. The work discussed in this review was supported by grants from the USPHS, CA90233 and CA98925, by NASA grant NAG2-1588, by the Stowers Institute for Medical Research, and by the DNA Sequencer Royalty Fund at Caltech.
Funders:
Funding AgencyGrant Number
CaltechUNSPECIFIED
NIHCA90233
NIHCA98925
NASANAG2-1588
Stowers Institute for Medical ResearchUNSPECIFIED
DNA Sequencer Royalty Fund, CaltechUNSPECIFIED
Issue or Number:1
PubMed Central ID:PMC4157939
Record Number:CaltechAUTHORS:20170207-082859641
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170207-082859641
Official Citation:David-Fung, E.-S., Yui, M. A., Morales, M., Wang, H., Taghon, T., Diamond, R. A. and Rothenberg, E. V. (2006), Progression of regulatory gene expression states in fetal and adult pro-T-cell development. Immunological Reviews, 209: 212–236. doi:10.1111/j.0105-2896.2006.00355.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74127
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Feb 2017 20:13
Last Modified:15 Jun 2020 18:24

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