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In vitro synthesis of infectious DNA of murine leukaemia virus

Rothenberg, Ellen and Smotkin, David and Baltimore, David and Weinberg, Robert A. (1977) In vitro synthesis of infectious DNA of murine leukaemia virus. Nature, 269 (5624). pp. 122-126. ISSN 0028-0836. http://resolver.caltech.edu/CaltechAUTHORS:20170207-083820520

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Abstract

DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/269122a0DOIArticle
http://www.nature.com/nature/journal/v269/n5624/abs/269122a0.htmlPublisherArticle
ORCID:
AuthorORCID
Rothenberg, Ellen0000-0002-3901-347X
Baltimore, David0000-0001-8723-8190
Additional Information:© 1977 Nature Publishing Group. Received 5 May: Accepted 20 June 1977. A preliminary account of these findings was presented at the Cold Spring Harbor meeting on RNA tumour Viruses, May 30, 1976. We would like to thank Daniel Donoghue for thoughtful advice and valuable criticism throughout this work. This research was supported by grants from the National Cancer Institute and the American Cancer Society and by a contract from the Virus Cancer Program of the National Cancer Institute. During part of this work, E.R. was supported by an NSF graduate fellowship. R.A.W. is a Cancer Research Scholar of the American Cancer Society, Massachusetts Division. D.B. is a Research Professor of the American Cancer Society.
Funders:
Funding AgencyGrant Number
National Cancer InstituteUNSPECIFIED
American Cancer Society, Massachusetts DivisionUNSPECIFIED
NSF Graduate Research FellowshipUNSPECIFIED
NIHUNSPECIFIED
Record Number:CaltechAUTHORS:20170207-083820520
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170207-083820520
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ID Code:74128
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Feb 2017 20:11
Last Modified:31 Oct 2017 17:45

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