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In vitro synthesis of infectious DNA of murine leukaemia virus

Rothenberg, Ellen and Smotkin, David and Baltimore, David and Weinberg, Robert A. (1977) In vitro synthesis of infectious DNA of murine leukaemia virus. Nature, 269 (5624). pp. 122-126. ISSN 0028-0836. doi:10.1038/269122a0.

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DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.

Item Type:Article
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Rothenberg, Ellen0000-0002-3901-347X
Baltimore, David0000-0001-8723-8190
Additional Information:© 1977 Nature Publishing Group. Received 5 May: Accepted 20 June 1977. A preliminary account of these findings was presented at the Cold Spring Harbor meeting on RNA tumour Viruses, May 30, 1976. We would like to thank Daniel Donoghue for thoughtful advice and valuable criticism throughout this work. This research was supported by grants from the National Cancer Institute and the American Cancer Society and by a contract from the Virus Cancer Program of the National Cancer Institute. During part of this work, E.R. was supported by an NSF graduate fellowship. R.A.W. is a Cancer Research Scholar of the American Cancer Society, Massachusetts Division. D.B. is a Research Professor of the American Cancer Society.
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National Cancer InstituteUNSPECIFIED
American Cancer Society, Massachusetts DivisionUNSPECIFIED
NSF Graduate Research FellowshipUNSPECIFIED
Issue or Number:5624
Record Number:CaltechAUTHORS:20170207-083820520
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74128
Deposited By: Tony Diaz
Deposited On:07 Feb 2017 20:11
Last Modified:11 Nov 2021 05:24

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