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Contributions of the Amygdala to Reward Expectancy and Choice Signals in Human Prefrontal Cortex

Hampton, Alan N. and Adolphs, Ralph and Tyszka, J. Michael and O'Doherty, John P. (2007) Contributions of the Amygdala to Reward Expectancy and Choice Signals in Human Prefrontal Cortex. Neuron, 55 (4). pp. 545-555. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20170208-105822480

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Abstract

The prefrontal cortex (PFC) receives substantial anatomical input from the amygdala, and these two structures have long been implicated in reward-related learning and decision making. Yet little is known about how these regions interact, especially in humans. We investigated the contribution of the amygdala to reward-related signals in PFC by scanning two rare subjects with focal bilateral amygdala lesions using fMRI. The subjects performed a reversal learning task in which they first had to learn which of two choices was the more rewarding, and then flexibly switch their choices when contingencies changed. Compared with healthy controls, both amygdala lesion subjects showed a profound change in ventromedial prefrontal cortex (vmPFC) activity associated with reward expectation and behavioral choice. These findings support a critical role for the human amygdala in establishing expected reward representations in PFC, which in turn may be used to guide behavioral choice.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.neuron.2007.07.022DOIArticle
http://www.sciencedirect.com/science/article/pii/S0896627307005430PublisherArticle
ORCID:
AuthorORCID
Adolphs, Ralph0000-0002-8053-9692
Tyszka, J. Michael0000-0001-9342-9014
Additional Information:© 2007 Elsevier Inc. Received 2 March 2007, Revised 14 June 2007, Accepted 16 July 2007, Available online 15 August 2007Published: August 15, 2007. This work was supported by a grant from the Gordon and Betty Moore Foundation (to J.O.D. and R.A.), the National Institutes of Health (to R.A.), and the Gimble Discovery Fund for Neuroscience (J.O.D).
Funders:
Funding AgencyGrant Number
Gordon and Betty Moore FoundationUNSPECIFIED
NIHUNSPECIFIED
Gimble Discovery FundUNSPECIFIED
Subject Keywords:Sysneuro; Humdisease
Issue or Number:4
Record Number:CaltechAUTHORS:20170208-105822480
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170208-105822480
Official Citation:Alan N. Hampton, Ralph Adolphs, J. Michael Tyszka, John P. O'Doherty, Contributions of the Amygdala to Reward Expectancy and Choice Signals in Human Prefrontal Cortex, Neuron, Volume 55, Issue 4, 16 August 2007, Pages 545-555, ISSN 0896-6273, http://dx.doi.org/10.1016/j.neuron.2007.07.022. (//www.sciencedirect.com/science/article/pii/S0896627307005430)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74157
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Feb 2017 20:05
Last Modified:03 Oct 2019 16:35

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