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Origins of lymphocyte developmental programs: transcription factor evidence

Rothenberg, Ellen V. and Pant, Rashmi (2004) Origins of lymphocyte developmental programs: transcription factor evidence. Seminars in Immunology, 16 (4). pp. 227-238. ISSN 1044-5323. doi:10.1016/j.smim.2004.08.002. https://resolver.caltech.edu/CaltechAUTHORS:20170208-151304962

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Abstract

This review explores the evolutionary origins of lymphocyte development by focusing on the transcription factors that direct mammalian lymphocyte development today. Gene expression data suggest that the programs to make lymphocytes involve the same transcription factor ensembles in all animals with lymphocytes. Most of these factors, GATA, Runx, PU.1/Spi, EBF/Olf, Ikaros, and Pax-2/5/8 family members, are also encoded in the genomes of animals without lymphocytes. We consider the functions of these factors in animals without lymphocytes in terms of discrete program components, which could have been assembled in a new way to create the lymphocyte developmental program ∼500 My ago.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.smim.2004.08.002DOIArticle
http://www.sciencedirect.com/science/article/pii/S1044532304000351PublisherArticle
ORCID:
AuthorORCID
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2004 Elsevier Ltd. Available online 6 October 2004. The authors are very grateful to Michele K. Anderson for her invaluable expertise, critical reading of the manuscript, and thoughtful discussions of this field throughout several years of collaboration with us, during which many of the ideas presented here were first developed. We also thank Marianne Bronner-Fraser, Eric H. Davidson, Max D. Cooper, Gary W. Litman, Daniel Rokhsar, Jonathan Rast, David McCauley, and Zeev Pancer for stimulating discussions and insights and for kindly sharing results before publication, and we thank Rochelle A. Diamond for expert management of the Rothenberg laboratory. This work was supported by grants from NASA, NAG2-1370, and NAG2-1588.
Funders:
Funding AgencyGrant Number
NASANAG2-1370
NASANAG2-1588
Subject Keywords:Phylogeny; Deuterostomes; T cell development; B cell development; Hematopoietic stem cells
Issue or Number:4
DOI:10.1016/j.smim.2004.08.002
Record Number:CaltechAUTHORS:20170208-151304962
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170208-151304962
Official Citation:Ellen V. Rothenberg, Rashmi Pant, Origins of lymphocyte developmental programs: transcription factor evidence, Seminars in Immunology, Volume 16, Issue 4, August 2004, Pages 227-238, ISSN 1044-5323, http://dx.doi.org/10.1016/j.smim.2004.08.002. (//www.sciencedirect.com/science/article/pii/S1044532304000351)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74171
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Feb 2017 23:49
Last Modified:11 Nov 2021 05:25

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