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Transcriptional regulation of lymphocyte lineage commitment

Rothenberg, Ellen V. and Telfer, Janice C. and Anderson, Michele K. (1999) Transcriptional regulation of lymphocyte lineage commitment. Bioessays, 21 (9). pp. 726-742. ISSN 0265-9247. doi:10.1002/(SICI)1521-1878(199909)21:9<726::AID-BIES4>3.0.CO;2-S.

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The development of T cells and B cells from pluripotent hematopoietic precursors occurs through a stepwise narrowing of developmental potential that ends in lineage commitment. During this process, lineage-specific genes are activated asynchronously, and lineage-inappropriate genes, although initially expressed, are asynchronously turned off. These complex gene expression events are the outcome of the changes in expression of multiple transcription factors with partially overlapping roles in early lymphocyte and myeloid cell development. Key transcription factors promoting B-cell development and candidates for this role in T-cell development are discussed in terms of their possible modes of action in fate determination. We discuss how a robust, stable, cell-type–specific gene expression pattern may be established in part by the interplay between endogenous transcription factors and signals transduced by cytokine receptors, and in part by the network of effects of particular transcription factors on each other.

Item Type:Article
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URLURL TypeDescription<726::AID-BIES4>3.0.CO;2-SDOIArticle;2-S/abstractPublisherArticle
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 1999 John Wiley & Sons, Inc. Issue online: 25 August 1999; Version of record online: 25 August 1999. Funding agencies: Stowers Institute for Medical Research; USPHS; Grant numbers: AI34041; AG13108. We apologize to the many colleagues whose important work could not be cited due to space constraints. The authors gratefully acknowledge the valuable criticism of Drs. Eric Davidson and Jonathan Rast, and helpful discussions with other members of the Rothenberg laboratory.
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Stowers Institute for Medical ResearchUNSPECIFIED
Issue or Number:9
Record Number:CaltechAUTHORS:20170208-155733709
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Official Citation:Rothenberg, E. V., Telfer, J. C. and Anderson, M. K. (1999), Transcriptional regulation of lymphocyte lineage commitment. Bioessays, 21: 726–742. doi:10.1002/(SICI)1521-1878(199909)21:9<726::AID-BIES4>3.0.CO;2-S
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74178
Deposited By: Tony Diaz
Deposited On:09 Feb 2017 00:25
Last Modified:11 Nov 2021 05:25

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