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Production of a Discrete, Infectious, Double-stranded DNA by Reverse Transcription in Virions of Moloney Murine Leukemia Virus

Baltimore, D. and Gilboa, E. and Rothenberg, E. and Yoshimura, F. (1979) Production of a Discrete, Infectious, Double-stranded DNA by Reverse Transcription in Virions of Moloney Murine Leukemia Virus. Cold Spring Harbor Symposia on Quantitative Biology, 43 . pp. 869-874. ISSN 0091-7451. http://resolver.caltech.edu/CaltechAUTHORS:20170213-071350586

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Abstract

One of the most unique viral replication schemes is that of the retroviruses (a class that includes the RNA tumor viruses). These viruses synthesize a double-stranded (DS) DNA copy of their single-stranded (SS) RNA genome as the initial event following infection of susceptible cells (see Weinberg 1977). The details of this process—called reverse transcription—are still obscure, but the general outlines have become clear during the last few years.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1101/SQB.1979.043.01.093DOIArticle
http://symposium.cshlp.org/content/43/869.extractPublisherArticle
ORCID:
AuthorORCID
Baltimore, D.0000-0001-8723-8190
Rothenberg, E.0000-0002-3901-347X
Additional Information:© 1979 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/). We are grateful to the M.I.T. Cell Culture Facility for providing the virus that made these studies possible. This work was supported by grants from the National Cancer Institute and by a contract from the Virus Cancer Program of the National Cancer Institute. D. B. is a Research Professor of the American Cancer Society. E. G. is a Dr. Chaim Weizmann postdoctoral fellow. F. Y. is a Special Fellow of the Leukemia Society of America.
Funders:
Funding AgencyGrant Number
National Cancer InstituteUNSPECIFIED
NIHUNSPECIFIED
American Cancer SocietyUNSPECIFIED
Leukemia Society of AmericaUNSPECIFIED
Weizmann InstituteUNSPECIFIED
Record Number:CaltechAUTHORS:20170213-071350586
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170213-071350586
Official Citation:Production of a Discrete, Infectious, Double-stranded DNA by Reverse Transcription in Virions of Moloney Murine Leukemia Virus D. Baltimore, E. Gilboa, E. Rothenberg, and F. Yoshimura Cold Spring Harb Symp Quant Biol 1979 43: 869-874; doi:10.1101/SQB.1979.043.01.093
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74221
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 Feb 2017 16:55
Last Modified:31 Oct 2017 17:55

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