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Semipermeable parylene membrane as an artificial Bruch's membrane

Lu, Bo and Liu, Zhao and Liu, Laura and Zhu, Danhong and Hinton, David and Thomas, Biju and Humayun, Mark S. and Tai, Yu-Chong (2011) Semipermeable parylene membrane as an artificial Bruch's membrane. In: 16th International Solid-State Sensors, Actuators and Microsystems Conference. IEEE , Piscataway, NJ, pp. 950-953. ISBN 978-1-4577-0156-6. https://resolver.caltech.edu/CaltechAUTHORS:20170213-164318264

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Abstract

This paper investigates the feasibility of a mesh-supported submicron-thick semipermeable parylene-C membrane as an artificial Bruch's membrane for the treatment of age-related macular degeneration (AMD). First, the permeabilities of parylene-C membranes with different thickness were measured and the results showed that as-deposited 0.30μm-thick parylene-C, which has a similar permeability to biological Bruch's membrane, is a good candidate to replace the diseased Bruch's membrane. This was further validated by perfusion cell culture experiments, in which nutrients were supplied to the cultured cells only by permeation through the submicron membrane. It was also found that retinal pigment epithelial (RPE) cells could grow and well-polarize with normal morphology on the membrane Finally, the implantation of the submicron-thick membrane (with in vitro cultured RPE cells) into rat's retina was successfully done with the help of a parylene-C/SU-8 microsurgical tool, and the following histological study of the retina showed that the reported thin parylene-C membrane could be a promissing RPE substrate candidate for further study.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/TRANSDUCERS.2011.5969376DOIArticle
http://ieeexplore.ieee.org/document/5969376/PublisherArticle
ORCID:
AuthorORCID
Liu, Zhao0000-0003-0370-2406
Humayun, Mark S.0000-0002-5830-5208
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2011 IEEE. This work is supported by CIRM, the California Institute for Regenerative Medicine, through University of Southern California.
Funders:
Funding AgencyGrant Number
California Institute for Regenerative Medicine (CIRM)UNSPECIFIED
Subject Keywords:Parylene, Semipermeable Membrane, Bruch's Membrane, Implantation
Record Number:CaltechAUTHORS:20170213-164318264
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170213-164318264
Official Citation:B. Lu et al., "Semipermeable parylene membrane as an artificial Bruch's membrane," 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, Beijing, 2011, pp. 950-953. doi: 10.1109/TRANSDUCERS.2011.5969376
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74282
Collection:CaltechAUTHORS
Deposited By: Kristin Buxton
Deposited On:14 Feb 2017 00:55
Last Modified:09 Mar 2020 13:18

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