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Discovery of a predicted gene arrangement in Drosophila azteca

Dobzhansky, Th. (1941) Discovery of a predicted gene arrangement in Drosophila azteca. Proceedings of the National Academy of Sciences of the United States of America, 27 (1). pp. 47-50. ISSN 0027-8424. https://resolver.caltech.edu/CaltechAUTHORS:DOBpnas39b

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Abstract

A method which under certain conditions permits prediction of as yet undiscovered gene arrangements was described a few years ago.(1,2) Its essence is as follows. If an inversion transforms the gene arrangement ABCDEFGH into AEDCBFGH, a second inversion taking place in the altered chromosome may be of the overlapping type, that is one of the breaks of the second inversion may lie within and the second break outside the limits of the first inversion. Thus the arrangement AEDCBFGH becomes AEDGFBCH. If the first and the third of these arrangements are known, one can postulate the existence of AEDCBFGH as a necessary intermediate step. If a family of gene arrangements related as overlapping inversions is known, a phylogenetic scheme indicating the lines of descent within this family may be drawn. Occasionally such phylogenetic schemes involve hypothetical links constructed with the aid of the method just outlined. The purpose of the present note is to record an instance of the discovery of such an hypothetical link, and certain related facts.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1073/pnas.27.1.47DOIUNSPECIFIED
Additional Information:© 1940 by the National Academy of Sciences. Received November 29, 1940.
Issue or Number:1
Record Number:CaltechAUTHORS:DOBpnas39b
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:DOBpnas39b
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7437
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Feb 2007
Last Modified:02 Oct 2019 23:42

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