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Alkane Oxidation: Methane Monooxygenases, Related Enzymes, and Their Biomimetics

Wang, Vincent C.-C. and Maji, Suman and Chen, Peter P.-Y. and Lee, Hung Kay and Yu, Steve S.-F. and Chan, Sunney I. (2017) Alkane Oxidation: Methane Monooxygenases, Related Enzymes, and Their Biomimetics. Chemical Reviews, 117 (13). pp. 8574-8621. ISSN 0009-2665. https://resolver.caltech.edu/CaltechAUTHORS:20170221-133527458

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Abstract

Methane monooxygenases (MMOs) mediate the facile conversion of methane into methanol in methanotrophic bacteria with high efficiency under ambient conditions. Because the selective oxidation of methane is extremely challenging, there is considerable interest in understanding how these enzymes carry out this difficult chemistry. The impetus of these efforts is to learn from the microbes to develop a biomimetic catalyst to accomplish the same chemical transformation. Here, we review the progress made over the past two to three decades toward delineating the structures and functions of the catalytic sites in two MMOs: soluble methane monooxygenase (sMMO) and particulate methane monooxygenase (pMMO). sMMO is a water-soluble three-component protein complex consisting of a hydroxylase with a nonheme diiron catalytic site; pMMO is a membrane-bound metalloenzyme with a unique tricopper cluster as the site of hydroxylation. The metal cluster in each of these MMOs harnesses O_2 to functionalize the C—H bond using different chemistry. We highlight some of the common basic principles that they share. Finally, the development of functional models of the catalytic sites of MMOs is described. These efforts have culminated in the first successful biomimetic catalyst capable of efficient methane oxidation without overoxidation at room temperature.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/acs.chemrev.6b00624DOIArticle
http://pubs.acs.org/doi/abs/10.1021/acs.chemrev.6b00624PublisherArticle
ORCID:
AuthorORCID
Yu, Steve S.-F.0000-0002-3462-065X
Chan, Sunney I.0000-0002-5348-2723
Additional Information:© 2017 American Chemical Society. Received: September 11, 2016; Published: February 16, 2017. This work was supported by the National Taiwan University and Academia Sinica Innovative Joint Program (NTU-SINICA-104R104502 and NTU-SINICA-105R104502) and the Academia Sinica Research Program on Nanoscience and Nanotechnology (2393-105-0200). V.C.-C. W. thanks Dr. Tiow-Gan Ong for financial support from Academia Sinica Career Development Award (104-CDA-M08). The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
National Taiwan UniversityNTU-SINICA-104R104502
National Taiwan UniversityNTU-SINICA-105R104502
Academia Sinica2393-105-0200
Academia Sinica104-CDA-M08
Issue or Number:13
Record Number:CaltechAUTHORS:20170221-133527458
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170221-133527458
Official Citation:Alkane Oxidation: Methane Monooxygenases, Related Enzymes, and Their Biomimetics Vincent C.-C. Wang, Suman Maji, Peter P.-Y. Chen, Hung Kay Lee, Steve S.-F. Yu, and Sunney I. Chan Chemical Reviews 2017 117 (13), 8574-8621 DOI: 10.1021/acs.chemrev.6b00624
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74432
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Feb 2017 21:58
Last Modified:09 Mar 2020 13:19

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