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Linkage variation and chromosome maps

Sturtevant, A. H. (1921) Linkage variation and chromosome maps. Proceedings of the National Academy of Sciences of the United States of America, 7 (7). pp. 181-183. ISSN 0027-8424. PMCID PMC1084843. doi:10.1073/pnas.7.7.181.

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A recent paper in this journal by Detlefsen(1) is introduced as follows: "There is a well intrenched concept of recent genetics that hereditary factors or genes may be given fairly definite loci on chromosome maps and that these maps correspond to or represent, roughly perhaps, the actual conditions in the chromosome. The basis for this attractive and suggestive view is the premise that the distance between two genes is necessarily proportional to the percentage of crossing over which these two genes show, other things being equal. If the distance which gives one per cent of crossovers is used as an arbitrary unit of measurement, then it follows that distances on the chromosome may be calculated in terms of this unit. It has seemed to me for some time that the antecedent in this hypothetical proposition contains a more or less gratuitous assumption. We do not know that the distance which gives 1% (or n%) of crossovers is a fixed unit. Stated differently we do not know how constant the percentage of crossing over may be between two genes to which we give a fixed distance, i.e., our arbitrary unit of measurement may itself prove to be a variable. It may be possible for the distance which gives 1% of crossing over to differ in different females of the same population, or differ between stocks. In order to throw some light on these questions I began a set of experiments in 1916..........."

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Additional Information:© 1921 by the National Academy of Sciences. Communicated by T. H. Morgan, March 10, 1921.
Issue or Number:7
PubMed Central ID:PMC1084843
Record Number:CaltechAUTHORS:STUpnas21a
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Official Citation:Linkage Variation and Chromosome Maps A. H. Sturtevant Proceedings of the National Academy of Sciences Jul 1921, 7 (7) 181-183; DOI: 10.1073/pnas.7.7.181
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7444
Deposited By: Tony Diaz
Deposited On:21 Feb 2007
Last Modified:08 Nov 2021 20:42

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