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Homogeneous Pd-Catalyzed Enantioselective Decarboxylative Protonation

Marinescu, Smaranda C. and Nishimata, Toyoki and Mohr, Justin T. and Stoltz, Brian M. (2008) Homogeneous Pd-Catalyzed Enantioselective Decarboxylative Protonation. Organic Letters, 10 (6). pp. 1039-1042. ISSN 1523-7060. PMCID PMC2966305. https://resolver.caltech.edu/CaltechAUTHORS:20170221-162726154

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Abstract

General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tertiary carbon stereocenters at the α-position are reported. The highly reactive catalyst tolerates a variety of substrate substitution and functionality, and generates enantioenriched cyclic ketones from racemic allyl β-ketoester starting materials.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ol702821jDOIArticle
http://pubs.acs.org/doi/suppl/10.1021/ol702821jPublisherSupporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966305/PubMed CentralArticle
ORCID:
AuthorORCID
Marinescu, Smaranda C.0000-0003-2106-8971
Mohr, Justin T.0000-0002-7005-3322
Stoltz, Brian M.0000-0001-9837-1528
Additional Information:© 2008 American Chemical Society. Received November 21, 2007. Publication Date (Web): February 28, 2008. We thank Sankyo Co., Ltd. (financial support of T.N.), Eli Lilly (predoctoral fellowship to J.T.M.), Amgen, and Bristol-Myers Squibb for generous funding.
Funders:
Funding AgencyGrant Number
Sankyo Co., Ltd.UNSPECIFIED
Eli LillyUNSPECIFIED
AmgenUNSPECIFIED
Bristol-Myers SquibbUNSPECIFIED
Issue or Number:6
PubMed Central ID:PMC2966305
Record Number:CaltechAUTHORS:20170221-162726154
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170221-162726154
Official Citation:Homogeneous Pd-Catalyzed Enantioselective Decarboxylative Protonation Smaranda C. Marinescu, Toyoki Nishimata, Justin T. Mohr, and Brian M. Stoltz Organic Letters 2008 10 (6), 1039-1042 DOI: 10.1021/ol702821j
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74444
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:22 Feb 2017 15:59
Last Modified:15 Jun 2020 19:56

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