Homogeneous Pd-Catalyzed Enantioselective Decarboxylative Protonation

Marinescu, Smaranda C. and Nishimata, Toyoki and Mohr, Justin T. and Stoltz, Brian M. (2008) Homogeneous Pd-Catalyzed Enantioselective Decarboxylative Protonation. Organic Letters, 10 (6). pp. 1039-1042. ISSN 1523-7060. PMCID PMC2966305. doi:10.1021/ol702821j. https://resolver.caltech.edu/CaltechAUTHORS:20170221-162726154

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Abstract

General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tertiary carbon stereocenters at the α-position are reported. The highly reactive catalyst tolerates a variety of substrate substitution and functionality, and generates enantioenriched cyclic ketones from racemic allyl β-ketoester starting materials.

Item Type:

Article

Related URLs:

URL	URL Type	Description
http://dx.doi.org/10.1021/ol702821j	DOI	Article
http://pubs.acs.org/doi/suppl/10.1021/ol702821j	Publisher	Supporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966305/	PubMed Central	Article

ORCID:

Author	ORCID
Marinescu, Smaranda C.	0000-0003-2106-8971
Mohr, Justin T.	0000-0002-7005-3322
Stoltz, Brian M.	0000-0001-9837-1528

Additional Information:

© 2008 American Chemical Society. Received November 21, 2007. Publication Date (Web): February 28, 2008. We thank Sankyo Co., Ltd. (financial support of T.N.), Eli Lilly (predoctoral fellowship to J.T.M.), Amgen, and Bristol-Myers Squibb for generous funding.

Funders:

Funding Agency	Grant Number
Sankyo Co., Ltd.	UNSPECIFIED
Eli Lilly	UNSPECIFIED
Amgen	UNSPECIFIED
Bristol-Myers Squibb	UNSPECIFIED

Issue or Number:

PubMed Central ID:

PMC2966305

DOI:

10.1021/ol702821j

Record Number:

CaltechAUTHORS:20170221-162726154

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:20170221-162726154

Official Citation:

Homogeneous Pd-Catalyzed Enantioselective Decarboxylative Protonation Smaranda C. Marinescu, Toyoki Nishimata, Justin T. Mohr, and Brian M. Stoltz Organic Letters 2008 10 (6), 1039-1042 DOI: 10.1021/ol702821j

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ID Code:

74444

Collection:

CaltechAUTHORS

Deposited By:

George Porter

Deposited On:

22 Feb 2017 15:59

Last Modified:

11 Nov 2021 05:27

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