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Self-degradation of heat shock proteins

Mitchell, Herschel K. and Petersen, Nancy S. and Buzin, Carolyn H. (1985) Self-degradation of heat shock proteins. Proceedings of the National Academy of Sciences of the United States of America, 82 (15). pp. 4969-4973. ISSN 0027-8424. PMCID PMC390479. doi:10.1073/pnas.82.15.4969. https://resolver.caltech.edu/CaltechAUTHORS:MITpnas85

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Abstract

The 70-kDa heat shock protein of Drosophila decays in vivo at a much faster rate than other abundantly labeled proteins. Degradation also occurs in vitro, even during electrophoresis. It appears that this degradation is not mediated by a general protease and that the 70-kDa heat shock protein has a slow proteolytic action upon itself. Heat-induced proteins in CHO cells and a mouse cell line also degrade spontaneously in vitro, as do certain non-heat shock proteins from Drosophila tissues as well as the cell lines.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1073/pnas.82.15.4969DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc390479/PubMed CentralArticle
Additional Information:© 1985 by the National Academy of Sciences. Communicated by Norman H. Horowitz, April 9, 1985. This work was supported by Public Health Service Grants GM25966B-06, GM33602, and HD-191-60 and a Biomedical Research Support Grant. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
NIHGM25966B-06
BIHGM33602
NIHHD-191-60
Subject Keywords:protease; stress proteins; Drosophila; mammalian cells
Issue or Number:15
PubMed Central ID:PMC390479
DOI:10.1073/pnas.82.15.4969
Record Number:CaltechAUTHORS:MITpnas85
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:MITpnas85
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7446
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Feb 2007
Last Modified:08 Nov 2021 20:42

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