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A Facile and Modular Synthesis of Phosphinooxazoline Ligands

Tani, Kousuke and Behenna, Douglas C. and McFadden, Ryan M. and Stoltz, Brian M. (2007) A Facile and Modular Synthesis of Phosphinooxazoline Ligands. Organic Letters, 9 (13). pp. 2529-2531. ISSN 1523-7060. doi:10.1021/ol070884s. https://resolver.caltech.edu/CaltechAUTHORS:20170222-151224179

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Abstract

The copper(I) iodide catalyzed phosphine/aryl halide coupling procedure of Buchwald et al. provides modular, robust, and scaleable access to phosphinooxazoline (PHOX) ligands. The advantages of this method are highlighted by the convenient synthesis of PHOX ligands with varied steric and electronic properties, which would be challenging to synthesize by other protocols.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ol070884sDOIArticle
http://pubs.acs.org/doi/suppl/10.1021/ol070884sRelated ItemSupporting Information
ORCID:
AuthorORCID
Stoltz, Brian M.0000-0001-9837-1528
Additional Information:© 2007 American Chemical Society. Received 16 April 2007. Published online 31 May 2007. Published in print 1 June 2007. The authors gratefully acknowledge Ono Pharmaceutical Co., Ltd. (postdoctoral fellowship to K.T.), The Fannie and John Hertz Foundation (predoctoral fellowship to D.C.B.), Eli Lilly and Co. (predoctoral funding to R.M.M.), California Institute of Technology, and Abbott, Amgen, Bristol-Myers Squibb, and Merck for financial support.
Funders:
Funding AgencyGrant Number
Ono Pharmaceutical Co. Ltd.UNSPECIFIED
Fannie and John Hertz FoundationUNSPECIFIED
Eli Lilly and Co.UNSPECIFIED
CaltechUNSPECIFIED
AbbottUNSPECIFIED
AmgenUNSPECIFIED
Bristol-Myers SquibbUNSPECIFIED
MerckUNSPECIFIED
Issue or Number:13
DOI:10.1021/ol070884s
Record Number:CaltechAUTHORS:20170222-151224179
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170222-151224179
Official Citation:A Facile and Modular Synthesis of Phosphinooxazoline Ligands Kousuke Tani, Douglas C. Behenna, Ryan M. McFadden, and Brian M. Stoltz Organic Letters 2007 9 (13), 2529-2531 DOI: 10.1021/ol070884s
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74475
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:23 Feb 2017 16:04
Last Modified:11 Nov 2021 05:27

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