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Amino acid sequence of a mouse immunoglobulin µ chain

Kehry, M. and Sibley, C. and Fuhrman, J. and Schilling, J. and Hood, L. E. (1979) Amino acid sequence of a mouse immunoglobulin µ chain. Proceedings of the National Academy of Sciences of the United States of America, 76 (6). pp. 2932-2936. ISSN 0027-8424.

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The complete amino acid sequence of the mouse µ chain from the BALB/c myeloma tumor MOPC 104E is reported. The Cµ region contains four consecutive homology regions of approximately 110 residues and a COOH-terminal region of 19 residues. A comparison of this µ chain from mouse with a complete µ sequence from human (Ou) and a partial µ chain sequence from dog (Moo) reveals a striking gradient of increasing homology from the NH2-terminal to the COOH-terminal portion of these µ chains, with the former being the least and the latter the most highly conserved. Four of the five sites of carbohydrate attachment appear to be at identical residue positions when the constant regions of the mouse and human µ chains are compared. The µ chain of MOPC 104E has a carbohydrate moiety attached in the second hypervariable region. This is particularly interesting in view of the fact that MOPC 104E binds α-(1→3)-dextran, a simple carbohydrate. The structural and functional constraints imposed by these comparative sequence analyses are discussed.

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Hood, L. E.0000-0001-7158-3678
Additional Information:© 1979 by the National Academy of Sciences. Communicated by Edward B. Lewis, March 26, 1979. We thank V. Farnsworth and M. W. Hunkapiller for patiently teaching techniques of peptide and amino acid sequence analyses. This work has been supported by National Institutes of Health Grants AI-10781 and CA-20314 and by a Gordon Ross Medical Foundation Fellowship to M.K. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. § 1734 solely to indicate this fact.
Subject Keywords:automated sequencer; immunoglobulin domain; myeloma tumor MOPC 104E; immunoglobulin evolution; carbohydrate attachment sites
Issue or Number:6
Record Number:CaltechAUTHORS:KEHpnas79
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7452
Deposited By: Tony Diaz
Deposited On:21 Feb 2007
Last Modified:03 Mar 2020 13:01

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