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Gas perfusable microfabricated membranes for high-density cell culture

Cook, Colin A. and Liu, Yang and Lu, Jianming and Chen, Nanhai and Fong, Yuman and Tai, Yu-Chong (2017) Gas perfusable microfabricated membranes for high-density cell culture. In: IEEE 30th International Conference on Micro Electro Mechanical Systems. IEEE , Piscataway, NJ, pp. 472-475. ISBN 978-1-5090-5078-9. http://resolver.caltech.edu/CaltechAUTHORS:20170302-134637147

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Abstract

We report for the first time the design, fabrication, and feasibility of a high-density cell culture system capable of a cell substrate density of 40 cm^2/cm^3, greater than 250× current commercially available systems. This design provides oxygen directly from gas perfusable membranes on which the cells are grown to overcome oxygen delivery limitations in traditional culture systems. With translation in mind, the membranes are composed only of medical grade PDMS and Parylene to mitigate contaminant leaching concerns.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/MEMSYS.2017.7863445 DOIArticle
http://ieeexplore.ieee.org/document/7863445/PublisherArticle
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2017 IEEE. Thanks to the Caltech MEMS Lab members for their guidance with techniques and fabrication. In memory of Lillian Boasie and Gweneth Goodman.
Record Number:CaltechAUTHORS:20170302-134637147
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170302-134637147
Official Citation:C. A. Cook, Y. Liu, J. Lu, N. Chen, Y. Fong and Y. C. Tai, "Gas perfusable microfabricated membranes for high-density cell culture," 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS), Las Vegas, NV, USA, 2017, pp. 472-475. doi: 10.1109/MEMSYS.2017.7863445 URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7863445&isnumber=7863316
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74672
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Mar 2017 03:18
Last Modified:03 Mar 2017 03:18

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