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Genetic dissection of lupus nephritis in murine models of SLE

Wakeland, Edward K. and Morel, Laurence and Mohan, Chandra and Yui, Mary (1997) Genetic dissection of lupus nephritis in murine models of SLE. Journal of Clinical Immunology, 17 (4). pp. 272-281. ISSN 0271-9142. https://resolver.caltech.edu/CaltechAUTHORS:20170303-140645475

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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with extremely heterogeneous clinical features, varying in pathogenicity from mild forms of the disease to those that advance relentlessly leading to progressive end organ damage. The underlying autoimmune disorder can express as a variety of immunologic abnormalities but generally results in the production of autoantibodies primarily directed against a spectrum of nuclear antigens. Much of the pathogenicity of SLE results from inflammatory processes initiated as a consequence of either the deposition of immune complexes or the targeting of autoantibodies to various anatomic sites. The most serious clinical consequences of SLE result from immune complex deposition in the kidney, resulting in lupus nephritis and culminating in kidney failure.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1023/A:1027370514198DOIArticle
https://link.springer.com/article/10.1023/A%3A1027370514198PublisherArticle
http://rdcu.be/qmrqPublisherFree ReadCube access
ORCID:
AuthorORCID
Yui, Mary0000-0002-3136-2181
Additional Information:© 1997 Plenum Publishing Corporation. Accepted: April 16, 1997.
Subject Keywords:Lupus nephritis; systemic lupus erythematosus; murine models; genetics
Issue or Number:4
Record Number:CaltechAUTHORS:20170303-140645475
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170303-140645475
Official Citation:Wakeland, E.K., Morel, L., Mohan, C. et al. J Clin Immunol (1997) 17: 272. doi:10.1023/A:1027370514198
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74713
Collection:CaltechAUTHORS
Deposited By: Donna Wrublewski
Deposited On:24 Mar 2017 18:57
Last Modified:03 Oct 2019 16:42

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