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Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: An approach for the genetic dissection of complex traits

Yui, M. A. and Muralidharan, K. and Moreno-Altamirano, B. and Perrin, G. and Chestnut, K. and Wakeland, E. K. (1996) Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: An approach for the genetic dissection of complex traits. Mammalian Genome, 7 (5). pp. 331-334. ISSN 0938-8990. https://resolver.caltech.edu/CaltechAUTHORS:20170303-142730717

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Abstract

Insulin-dependent (Type 1) diabetes (IDD) in the NOD mouse is inherited as a complex polygenic trait making the identification of susceptibility genes difficult. Currently none of the non-MHC IDD susceptibility genes in NOD have been identified. In this paper we describe the congenic mouse approach that we are using for the dissection of complex traits, such as IDD. We produced a series of six congenic strains carrying NOD-derived diabetogenic genomic intervals, which were previously identified by linkage analysis, on a resistant background. These congenic strains were produced for the purpose of characterizing the function of each of these genes, alone and in combinations, in IDD pathogenesis and to allow fine mapping of the NOD IDD susceptibility genes. Histological examination of pancreata from 6 to 8-month-old congenic mice reveals that intervals on Chromosomes (Chrs) 1 and 17, but not 3, 6, and 11, contain NOD-derived genes that can increase the trafficking of mononuclear cells into the pancreas. Insulitis was observed only very rarely, even in older congenic mice, indicating that multiple genes are required for this phenotype. These results demonstrate the utility of this congenic approach for the study of complex genetic traits.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s003359900097DOIArticle
https://link.springer.com/article/10.1007/s003359900097PublisherArticle
ORCID:
AuthorORCID
Yui, M. A.0000-0002-3136-2181
Additional Information:© Springer-Verlag 1996. Received: 01 September 1995. Accepted: 20 December 1995.
Issue or Number:5
Record Number:CaltechAUTHORS:20170303-142730717
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170303-142730717
Official Citation:Yui, M.A., Muralidharan, K., Moreno-Altamirano, B. et al. Mammalian Genome (1996) 7: 331. doi:10.1007/s003359900097
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74717
Collection:CaltechAUTHORS
Deposited By: Donna Wrublewski
Deposited On:24 Mar 2017 20:32
Last Modified:03 Oct 2019 16:42

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