Gibbs, Richard A. and Pachter, Lior (2004) Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature, 428 (6982). pp. 493-521. ISSN 0028-0836. doi:10.1038/nature02426. https://resolver.caltech.edu/CaltechAUTHORS:20170308-145138306
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Abstract
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.
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Additional Information: | © 2004 Macmillan Publishers Limited. Received 31 December 2003; Accepted 20 February 2004. Work at Baylor College of Medicine was supported by a grant from the NHGRI and NHLBI to R.A.G. Work at Genome Therapeutics was supported by grants from the NHGRI to D.S. A.S. acknowledges support from the NIGMS. M.B. acknowledges support from the NIH. N.H. was supported by the NGFN/BMBF (German Ministry for Research and Education). B.J.T. and J.M.Y. are supported by an NIH grant from the NIDCD. K.M.R. and G.M.C. are Howard Hughes Medical Institute Predoctoral Fellows. L.M.D'S., K.M. and K.J.K. are supported by training fellowships from the W. M. Keck Foundation to the Gulf Coast Consortia through the Keck Center for Computational and Structural Biology. Work at Case Western Reserve was supported in part by NIH grants to E.E.E. Work at IMIM was supported by a grant from Plan Nacional de I + D (Spain). M.M.A. acknowledges support from programme Ramón y Cajal and a grant from the Spanish Ministry of Science and Technology. Work at Universidad de Oviedo was supported by grants from the European Union, Obra Social Cajastur and Gobierno del Principado de Asturias. Work at Penn State University was supported by NHGRI grants. Work at the University of California Berkeley was supported by a grant from the NIH. Work at the Washington University School of Medicine Genome Sequencing Center and the British Columbia Cancer Agency Genome Sciences Centre was supported by an NIH grant. Work at UCSC and CHORI was supported by the NHGRI. The author declares no competing financial interests. | ||||||||||||||||||||||||||||
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Issue or Number: | 6982 | ||||||||||||||||||||||||||||
DOI: | 10.1038/nature02426 | ||||||||||||||||||||||||||||
Record Number: | CaltechAUTHORS:20170308-145138306 | ||||||||||||||||||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20170308-145138306 | ||||||||||||||||||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||||||||||||||
ID Code: | 74926 | ||||||||||||||||||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||||||||||||||||||
Deposited By: | George Porter | ||||||||||||||||||||||||||||
Deposited On: | 09 Mar 2017 15:32 | ||||||||||||||||||||||||||||
Last Modified: | 15 Nov 2021 16:29 |
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