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Mapping and identification of essential gene functions on the X chromosome of Drosophila

Peter, Annette and Pachter, Lior (2002) Mapping and identification of essential gene functions on the X chromosome of Drosophila. EMBO Reports, 3 (1). pp. 34-38. ISSN 1469-221X. PMCID PMC1083931. doi:10.1093/embo-reports/kvf012.

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The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics Systems, have sequenced the genome, complementing the previously established physical and genetic maps. In addition, the Berkeley Drosophila Genome Project has undertaken large‐scale functional analysis based on mutagenesis by transposable P element insertions into autosomes. Here, we present a large‐scale P element insertion screen for vital gene functions and a BAC tiling map for the X chromosome. A collection of 501 X‐chromosomal P element insertion lines was used to map essential genes cytogenetically and to establish short sequence tags (STSs) linking the insertion sites to the genome. The distribution of the P element integration sites, the identified genes and transcription units as well as the expression patterns of the P‐element‐tagged enhancers is described and discussed.

Item Type:Article
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URLURL TypeDescription CentralArticle
Pachter, Lior0000-0002-9164-6231
Additional Information:© 2002 European Molecular Biology Organization. Received October 11, 2001; revised and accepted November 22, 2001. We thank many colleagues for their help. This work was supported by the German Human Genome Project (grant 01 KW 9632/9) and a contract from the European Commission.
Funding AgencyGrant Number
Deutsche Humangenomprojekt01 KW 9632/9
European CommissionUNSPECIFIED
Issue or Number:1
PubMed Central ID:PMC1083931
Record Number:CaltechAUTHORS:20170309-095230836
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74971
Deposited By: George Porter
Deposited On:10 Mar 2017 22:21
Last Modified:15 Nov 2021 16:29

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