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Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons

Dubchak, Inna and Brudno, Michael and Loots, Gabriela G. and Pachter, Lior and Mayor, Chris and Rubin, Edward M. and Frazer, Kelly A. (2000) Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons. Genome Research, 10 (9). pp. 1304-1306. ISSN 1088-9051. PMCID PMC310906. https://resolver.caltech.edu/CaltechAUTHORS:20170309-111029375

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Abstract

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time. [The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF276990.]


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/0.1101/gr.142200DOIArticle
http://genome.cshlp.org/content/10/9/1304.abstractPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310906/PubMed CentralArticle
ORCID:
AuthorORCID
Pachter, Lior0000-0002-9164-6231
Additional Information:© 2000 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/). Received March 28, 2000. Accepted July 12, 2000. We thank Keith Lewis, Willow Dean, and Cathy Blankespoor for DNA sequencing and Nila Patil for valuable remarks on the manuscript. This work was supported by the following grants: U.S. Department of Energy contract DE-AC376SF00098 and NIH GM-5748202 (K.A.F.) The publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
Department of Energy (DOE)DE-AC03-76SF00098
NIHGM-5748202
Issue or Number:9
PubMed Central ID:PMC310906
Record Number:CaltechAUTHORS:20170309-111029375
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170309-111029375
Official Citation:Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons Inna Dubchak, Michael Brudno, Gabriela G. Loots, Lior Pachter, Chris Mayor, Edward M. Rubin, and Kelly A. Frazer Genome Res. September 1, 2000 10: 1304-1306; doi:10.1101/gr.142200
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74979
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:10 Mar 2017 03:49
Last Modified:24 Feb 2020 10:30

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