CaltechAUTHORS
  A Caltech Library Service

Human and mouse gene structure: comparative analysis and application to exon prediction

Batzoglou, Serafim and Pachter, Lior and Mesirov, Jill and Berger, Bonnie and Lander, Eric S. (2000) Human and mouse gene structure: comparative analysis and application to exon prediction. In: Proceedings of the fourth annual international conference on Computational molecular biology (RECOMB '00). ACM , New York, NY, pp. 46-53. ISBN 1-58113-186-0. https://resolver.caltech.edu/CaltechAUTHORS:20170309-111631818

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20170309-111631818

Abstract

We describe a novel analytical approach to gene recognition based on cross-species comparison We first undertook a comparison of orthologous genomic look from human and mouse, studying the extent of similarity in the number, size and sequence of exons and introns We then developed an approach for recognizing genes within such orthologous regions, by first aligning the regions using an iterative global alignment system and then identifying genes based on conservation of exonic features at aligned positions in both species The alignment and gene recognition are performed by new programs called GLASS and ROSETTA, respectively ROSETTA performed well at exact identification of coding exons in 117 orthologous pairs tested.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1145/332306.332326DOIArticle
http://dl.acm.org/citation.cfm?id=332326PublisherArticle
ORCID:
AuthorORCID
Pachter, Lior0000-0002-9164-6231
Lander, Eric S.0000-0003-2662-4631
Additional Information:© 2000 ACM. S B, B B and this work were supported in part by Merck, L P was supported by a PMMB fellowship and by an NIH training grant. E S L and J M were supported in part by a grant from the National Human Genome Research Institute We thank Bruce Birren, Ken Dewar, and Daniel Kleitman for helpful discussions We thank Eric Banks for support with software development
Funders:
Funding AgencyGrant Number
MerckUNSPECIFIED
Program in Mathematics and Molecular BiologyUNSPECIFIED
NIH Predoctoral FellowshipUNSPECIFIED
Subject Keywords:Gene Recognition, Global Alignments, Comparative Genomics
Record Number:CaltechAUTHORS:20170309-111631818
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170309-111631818
Official Citation:Serafim Batzoglou, Lior Pachter, Jill Mesirov, Bonnie Berger, and Eric S. Lander. 2000. Human and mouse gene structure: comparative analysis and application to exon prediction. In Proceedings of the fourth annual international conference on Computational molecular biology (RECOMB '00), Ron Shamir, Satoru Miyano, Sorin Istrail, Pavel Pevzner, and Michael Waterman (Eds.). ACM, New York, NY, USA, 46-53. DOI=http://dx.doi.org/10.1145/332306.332326
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:74980
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:13 Mar 2017 15:26
Last Modified:09 Mar 2020 13:18

Repository Staff Only: item control page