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Methods to investigate the structure and connectivity of the nervous system

Lee, Donghyung and Huang, Ting-Hao and De La Cruz, Aubrie and Callejas, Antuca and Lois, Carlos (2017) Methods to investigate the structure and connectivity of the nervous system. Fly, 11 (3). pp. 224-238. ISSN 1933-6934. PMCID PMC5552278. http://resolver.caltech.edu/CaltechAUTHORS:20170313-090548194

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Abstract

Understanding the computations that take place in neural circuits requires identifying how neurons in those circuits are connected to one another. In addition, recent research indicates that aberrant neuronal wiring may be the cause of several neurodevelopmental disorders, further emphasizing the importance of identifying the wiring diagrams of brain circuits. To address this issue, several new approaches have been recently developed. In this review, we describe several methods that are currently available to investigate the structure and connectivity of the brain, and discuss their strengths and limitations.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1080/19336934.2017.1295189DOIArticle
http://www.tandfonline.com/doi/full/10.1080/19336934.2017.1295189PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552278/PubMed CentralArticle
Additional Information:© 2017 Donghyung Lee, Ting-Hao Huang, Aubrie De La Cruz, Antuca Callejas, and Carlos Lois. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/ 4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. Received 06 Jan 2017, Accepted 08 Feb 2017, Accepted author version posted online: 16 Feb 2017. No potential conflicts of interest were disclosed.
Subject Keywords:brain circuit; connectomics; neuron; synapse; wiring diagram
PubMed Central ID:PMC5552278
Record Number:CaltechAUTHORS:20170313-090548194
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170313-090548194
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75051
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Mar 2017 16:14
Last Modified:17 Aug 2017 15:57

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