A Caltech Library Service

Methods to investigate the structure and connectivity of the nervous system

Lee, Donghyung and Huang, Ting-hao and De La Cruz, Aubrie and Callejas, Antuca and Lois, Carlos (2017) Methods to investigate the structure and connectivity of the nervous system. Fly, 11 (3). pp. 224-238. ISSN 1933-6934. PMCID PMC5552278.

[img] PDF - Published Version
Creative Commons Attribution Non-commercial No Derivatives.

[img] MS Excel (Table 1 - An overview of the advantages and disadvantages associated with each method of identifying synaptic connections) - Supplemental Material
Creative Commons Attribution Non-commercial No Derivatives.


Use this Persistent URL to link to this item:


Understanding the computations that take place in neural circuits requires identifying how neurons in those circuits are connected to one another. In addition, recent research indicates that aberrant neuronal wiring may be the cause of several neurodevelopmental disorders, further emphasizing the importance of identifying the wiring diagrams of brain circuits. To address this issue, several new approaches have been recently developed. In this review, we describe several methods that are currently available to investigate the structure and connectivity of the brain, and discuss their strengths and limitations.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Huang, Ting-hao0000-0002-2546-3525
De La Cruz, Aubrie0000-0002-7351-0285
Callejas, Antuca0000-0002-2236-9197
Lois, Carlos0000-0002-7305-2317
Additional Information:© 2017 Donghyung Lee, Ting-Hao Huang, Aubrie De La Cruz, Antuca Callejas, and Carlos Lois. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License ( 4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. Received 06 Jan 2017, Accepted 08 Feb 2017, Accepted author version posted online: 16 Feb 2017. No potential conflicts of interest were disclosed.
Subject Keywords:brain circuit; connectomics; neuron; synapse; wiring diagram
Issue or Number:3
PubMed Central ID:PMC5552278
Record Number:CaltechAUTHORS:20170313-090548194
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75051
Deposited By: Tony Diaz
Deposited On:13 Mar 2017 16:14
Last Modified:26 Feb 2020 23:44

Repository Staff Only: item control page