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Measurement of tissue optical properties by the use of oblique-incidence optical fiber reflectometry

Lin, Shao-Pow and Wang, Lihong and Jacques, Steven L. and Tittel, Frank K. (1997) Measurement of tissue optical properties by the use of oblique-incidence optical fiber reflectometry. Applied Optics, 36 (1). pp. 136-143. ISSN 0003-6935. doi:10.1364/AO.36.000136.

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Fiber-optic-based oblique-incidence reflectometry is a simple and accurate method for measuring the absorption and reduced scattering coefficients μ_a and μ_s' of semi-infinite turbid media. Obliquely incident light produces a spatial distribution of diffuse reflectance that is not centered about the point of light entry. The amount of shift in the center of diffuse reflectance is directly related to the medium’s diffusion length D. We developed a fiber-optic probe to deliver light obliquely and sample the relative profile of diffuse reflectance. Measurement in absolute units is not necessary. From the profile, it was possible to measure D, perform a curve fit for the effective attenuation coefficient μ_(eff), and then calculate μ_a and μ_s'. This method was verified with Monte Carlo simulations and tested on tissue phantoms. Our measurements of D and μ_(eff) had an accuracy of approximately 5%, thus giving us 10% and 5% accuracy for μ_a and μ_s', respectively.

Item Type:Article
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Wang, Lihong0000-0001-9783-4383
Additional Information:© 1997 Optical Society of America. Received 4 March 1996; revised manuscript received 17 September 1996. This project was sponsored in part by The Whitaker Foundation, U.S. National Institutes of Health grants R29 CA68562 and R29 HL45045, and the U.S. Department of Energy grant DE-FG05-91ER61226.
Funding AgencyGrant Number
Whitaker FoundationUNSPECIFIED
NIHR29 CA68562
NIHR29 HL45045
Department of Energy (DOE)DE-FG05-91ER61226
Subject Keywords:Tissue optics, fiber optics, biomedical optics, turbid media, scattering media, optical properties, reflectometry, oblique incidence
Issue or Number:1
Record Number:CaltechAUTHORS:20170313-142220904
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Official Citation:Shao-Pow Lin, Lihong Wang, Steven L. Jacques, and Frank K. Tittel, "Measurement of tissue optical properties by the use of oblique-incidence optical fiber reflectometry," Appl. Opt. 36, 136-143 (1997)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75069
Deposited By: Tony Diaz
Deposited On:13 Mar 2017 22:22
Last Modified:15 Nov 2021 16:30

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