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Optimal beam size for light delivery to absorption-enhanced tumors buried in biological tissues and effect of multiple-beam delivery: a Monte Carlo study

Wang, Lihong V. and Nordquist, Robert E. and Chen, Wei R. (1997) Optimal beam size for light delivery to absorption-enhanced tumors buried in biological tissues and effect of multiple-beam delivery: a Monte Carlo study. Applied Optics, 36 (31). pp. 8286-8291. ISSN 0003-6935. https://resolver.caltech.edu/CaltechAUTHORS:20170313-143338769

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Abstract

Optimal laser light delivery into turbid biological tissues was studied by using Monte Carlo simulations based on the delta-scattering technique. The goal was to deliver efficiently the maximum amount of optical power into buried tumors being treated while avoiding potential damage to normal tissue caused by strong optical power deposition underneath the tissue surface illuminated by the laser beam. The buried tumors were considered to have much higher absorption than the surrounding normal tissue because of selective uptake of the absorption-enhancement dye. The power delivering efficiency to buried tumors was investigated for various diameters of the laser beam. An optimal beam diameter was estimated to achieve the maximum product of the power coupling efficiency and the power delivered to the buried tumor. The distribution of power deposition was simulated for single-beam delivery and multiple-beam delivery as well. The simulated results showed that with an appropriate dye enhancement and an optimal laser delivery configuration, a high selectivity for laser treatment of tumor could be achieved.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1364/AO.36.008286DOIArticle
https://www.osapublishing.org/ao/abstract.cfm?uri=ao-36-31-8286PublisherArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 1997 Optical Society of America. Received 6 March 1997; revised manuscript received 13 June 1997. This project was sponsored in part by the National Institutes of Health grant R29 CA68562 and The Whitaker Foundation.
Funders:
Funding AgencyGrant Number
NIHR29 CA68562
Whitaker FoundationUNSPECIFIED
Subject Keywords:Monte Carlo, light delivery, optical therapy, turbid media, biological tissues
Issue or Number:31
Record Number:CaltechAUTHORS:20170313-143338769
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170313-143338769
Official Citation:Lihong V. Wang, Robert E. Nordquist, and Wei R. Chen, "Optimal beam size for light delivery to absorption-enhanced tumors buried in biological tissues and effect of multiple-beam delivery: a Monte Carlo study," Appl. Opt. 36, 8286-8291 (1997)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75071
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Mar 2017 22:22
Last Modified:03 Oct 2019 16:46

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