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The influence of boundary conditions on the accuracy of diffusion theory in time-resolved reflectance spectroscopy of biological tissues

Hielscher, Andreas H. and Jacques, Steven L. and Wang, Lihong and Tittel, Frank K. (1995) The influence of boundary conditions on the accuracy of diffusion theory in time-resolved reflectance spectroscopy of biological tissues. Physics in Medicine and Biology, 40 (11). pp. 1957-1975. ISSN 0031-9155. doi:10.1088/0031-9155/40/11/013. https://resolver.caltech.edu/CaltechAUTHORS:20170313-150303167

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Abstract

The applicability of diffusion theory for the determination of tissue optical properties from time-resolved reflectance spectroscopy is investigated. Analytical expressions from diffusion theory using the three most commonly assumed boundary conditions at the air-tissue interface are compared with time-resolved Monte Carlo simulations and measurements on tissue phantoms. The effects of the choice of the boundary conditions on the accuracy of the findings for the optical parameters are quantified, and criteria for accurate curve-fitting algorithms are developed.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1088/0031-9155/40/11/013DOIArticle
http://iopscience.iop.org/article/10.1088/0031-9155/40/11/013/metaPublisherArticle
ORCID:
AuthorORCID
Wang, Lihong0000-0001-9783-4383
Additional Information:© 1995 IOP Publishing Ltd. Received 30 January 1995, in final form 30 June 1995. The authors would like to thank Dr H Liu and Professor B Chance from the Department of Biochemistry and Biophysics at the University of Pennsylvania for support in the experimental set-up and the careful review of the paper. Furthermore the help of D Boas with the calculation of the scattering coefficient of the polystyrene sphere solutions is appreciated. This work was supported by the Robert A Welch Foundation, the Department of Energy, and NIH (R29-HL45045).
Funders:
Funding AgencyGrant Number
Robert A. Welch FoundationUNSPECIFIED
Department of Energy (DOE)UNSPECIFIED
NIHR29-HL45045
Issue or Number:11
DOI:10.1088/0031-9155/40/11/013
Record Number:CaltechAUTHORS:20170313-150303167
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170313-150303167
Official Citation:A H Hielscher et al 1995 Phys. Med. Biol. 40 1957
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75074
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Mar 2017 22:18
Last Modified:15 Nov 2021 16:30

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