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Ex Vivo implantation study of minimally invasive glaucoma drainage device

Lin, Jeffrey Chun-Hui and Yu, Feiqiao and Saati, Saloomeh and Varma, Rohit and Humayun, Mark S. and Tai, Yu-Chong (2010) Ex Vivo implantation study of minimally invasive glaucoma drainage device. In: IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems. IEEE , Piscataway, NJ, pp. 321-324. ISBN 978-1-4244-6545-3. http://resolver.caltech.edu/CaltechAUTHORS:20170314-161916848

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Abstract

We present in this paper the first ex vivo implantation results of our minimally invasive glaucoma drainage device (GDD.) The GDD is designed to treat glaucoma patients by draining out their extraneous aqueous humor out of the anterior chamber utilizing a MEMS micro-fluidic normally closed (NC) check valve. The NC check valve is encapsulated in protective tubing made from parylene C, which has been proved to be biocompatible in implantation. A new packaging and a bench-top testing procedure is established to characterize the integrated GDD prior to its implantation into enucleated porcine eyes. Pre-implanted characterization curve demonstrates a cracking pressure of 10–20 mmHg of the NC check valve, which agrees with our theoretical design. Ex vivo implantation results show that cracking pressure is measured as 24 mmHg by unloading the eye pressure. The little offset of the cracking pressure comes from the differences between the in vitro and ex vivo testing environments. The hysteresis behavior of the NC check valve is also examined during implantation and is presented here.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/NEMS.2010.5592223DOIArticle
http://ieeexplore.ieee.org/document/5592223/PublisherArticle
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2010 IEEE. The authors would like to thank Dr. Trevor Ropers technical assistance in terms of device fabrication.
Subject Keywords:glaucoma; micro check valves; microfluidics; paryelene; microelectromechanical systems
Record Number:CaltechAUTHORS:20170314-161916848
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170314-161916848
Official Citation:J. C. H. Lin, F. Yu, S. Saati, R. Varma, M. S. Humayun and Y. C. Tai, "Ex Vivo implantation study of minimally invasive glaucoma drainage device," 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, Xiamen, 2010, pp. 321-324. doi: 10.1109/NEMS.2010.5592223
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75120
Collection:CaltechAUTHORS
Deposited By: Kristin Buxton
Deposited On:16 Mar 2017 17:32
Last Modified:16 Mar 2017 17:32

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