Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in tissue cultures of rat erythroleukemia cells transformed by 7,12-dimethylbenz(a)anthracene

Kluge, N. and Ostertag, W. and Sugiyama, T. and Arndt-Jovin, D. and Steinheider, G. and Furusawa, M. and Dube, S. K. (1976) Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in tissue cultures of rat erythroleukemia cells transformed by 7,12-dimethylbenz(a)anthracene. Proceedings of the National Academy of Sciences of the United States of America, 73 (4). pp. 1237-1240. ISSN 0027-8424. PMCID PMC430237. https://resolver.caltech.edu/CaltechAUTHORS:KLUpnas76

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Abstract

Permanent cell lines from transplantable tumors from 7,12-dimethylbenz(a)anthracene-induced erythroleukemia of the rat were established. These cell lines maintain their erythroid nature. Erythroid differentiation can be induced by dimethylsulfoxide. This is shown by decrease in cell size, appearance of red and benzidine positive cells, and induced synthesis of four out of six adult globin chains.

Item Type:

Article

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URL	URL Type	Description
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC430237/	PubMed Central	Article
http://www.pnas.org/cgi/content/abstract/73/4/1237	Other	UNSPECIFIED
http://www.pnas.org/cgi/content/abstract/73/4/1237	Other	UNSPECIFIED

Additional Information:

© 1976 National Academy of Sciences. Communicated by Charles Huggins, January 2, 1976. We thank Mrs. A. Rohmann and Mrs. U. Ries for assistance. The work was supported by a research stipend (G.S.) and by a grant (W.O.) from the Deutsche Forschungsgemeinschaft.

Funders:

Funding Agency	Grant Number
Deutsche Forschungsgemeinschaft (DFG)	UNSPECIFIED

Subject Keywords:

erythropoiesis; cell size analysis; Friend virus; Friend cells

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PubMed Central ID:

PMC430237

Record Number:

CaltechAUTHORS:KLUpnas76

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:KLUpnas76

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No commercial reproduction, distribution, display or performance rights in this work are provided.

ID Code:

7522

Collection:

CaltechAUTHORS

Deposited By:

Tony Diaz

Deposited On:

01 Mar 2007

Last Modified:

02 Oct 2019 23:42

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