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Vibrioanguillarum antigen stimulates mitogenesis and polyclonal activation of salmonid lymphocytes

Yui, Mary A. and Kaattari, Stephen L. (1987) Vibrioanguillarum antigen stimulates mitogenesis and polyclonal activation of salmonid lymphocytes. Developmental and Comparative Immunology, 11 (3). pp. 539-549. ISSN 0145-305X. https://resolver.caltech.edu/CaltechAUTHORS:20170324-081103820

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Abstract

An antigen preparation of Vibrioanguillarum, a salmonid pathogen, acts as a potent invitro mitogenic stimulator of splenic and pronephric (anterior kidney) lymphocytes from coho salmon (Oncorhynchuskisutch), chinook salmon (O.tshawytscha) and rainbow trout (Salmogairdneri). This antigen (VA) is comparable in its mitogenic activity to Concanavalin A (Con A), Escherichiacoli lipopolysaccharide (LPS), and phytohemagglutinin (PHA). VA gives peak mitogenic responses in coho five days after initiation of cell culture. VA also appears to be a nonspecific polyclonal activator as determined by the generation of plaque forming cells to trinitrophenyl (TNP) and fluorescein (FI) haptenic determinants. Chemical characterization is limited, but it appears that Vibrio LPS could be responsible for these activities.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0145-305X(87)90043-7DOIArticle
http://www.sciencedirect.com/science/article/pii/0145305X87900437PublisherArticle
ORCID:
AuthorORCID
Yui, Mary A.0000-0002-3136-2181
Additional Information:© 1987 Elsevier.
Issue or Number:3
Record Number:CaltechAUTHORS:20170324-081103820
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170324-081103820
Official Citation:Mary A. Yui, Stephen L. Kaattari, Vibrioanguillarum antigen stimulates mitogenesis and polyclonal activation of salmonid lymphocytes, Developmental & Comparative Immunology, Volume 11, Issue 3, 1987, Pages 539-549, ISSN 0145-305X, http://dx.doi.org/10.1016/0145-305X(87)90043-7. (http://www.sciencedirect.com/science/article/pii/0145305X87900437)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75371
Collection:CaltechAUTHORS
Deposited By: Donna Wrublewski
Deposited On:24 Mar 2017 16:50
Last Modified:03 Oct 2019 16:49

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