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Widespread antigenic cross-reactivity between plasma proteins of a gastropod, and its trematode parasite

Bayne, Christopher J. and Boswell, Carl A. and Yui, Mary A. (1987) Widespread antigenic cross-reactivity between plasma proteins of a gastropod, and its trematode parasite. Developmental and Comparative Immunology, 11 (2). pp. 321-329. ISSN 0145-305X. https://resolver.caltech.edu/CaltechAUTHORS:20170324-081913330

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Abstract

Evidence obtained earlier with immunofluorescence and immunoelectron microscopy was interpreted to imply molecular mimicry of the host Biomphalariaglabrata by the parasite Schistosomamansoni. Using Western Blotting, we find that “mimicry” is due to widespread shared epitopes. Furthermore, at least one individual plasma protein of B. glabrata shares epitopes with the majority of plasma proteins in the mollusc. The widespread antigenic determinants may be carbohydrates. Caution is warranted when antisera, raised in mammals against heterogeneous invertebrate extracts, are used to screen for related antigenic determinants.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0145-305X(87)90076-0PublisherArticle
http://www.sciencedirect.com/science/article/pii/0145305X87900760PublisherArticle
ORCID:
AuthorORCID
Yui, Mary A.0000-0002-3136-2181
Additional Information:© 1987 Elsevier.
Issue or Number:2
Record Number:CaltechAUTHORS:20170324-081913330
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170324-081913330
Official Citation:Christopher J. Bayne, Carl A. Boswell, Mary A. Yui, Widespread antigenic cross-reactivity between plasma proteins of a gastropod, and its trematode parasite, Developmental & Comparative Immunology, Volume 11, Issue 2, 1987, Pages 321-329, ISSN 0145-305X, http://dx.doi.org/10.1016/0145-305X(87)90076-0. (http://www.sciencedirect.com/science/article/pii/0145305X87900760)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75372
Collection:CaltechAUTHORS
Deposited By: Donna Wrublewski
Deposited On:24 Mar 2017 16:48
Last Modified:03 Oct 2019 16:49

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