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Polyclonal activation of salmonid B lymphocytes

Kaattari, Stephen L. and Yui, Mary A. (1987) Polyclonal activation of salmonid B lymphocytes. Developmental and Comparative Immunology, 11 (1). pp. 155-165. ISSN 0145-305X. doi:10.1016/0145-305X(87)90017-6.

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The process of invitro polyclonal activation of coho salmon (Oncorhynchuskisutch) lymphocytes was examined with respect to the induction of mitogenesis, total immunoglobulin production, and the production of specific antibodies or plaque forming cells. These studies demonstrate that antigen specific stimulation of antibody production is not linked to mitogenic activity, or total immunoglobulin production, while the polyclonal activation of specific antibody production is closely linked to these functions. Stimulation of immunoglobulin production by phytohemagglutinin suggests that this mitogen may not be limited to T cell activation in salmonids or, alternatively, it may induce the production of lymphokines capable of polyclonally activating B cells. Further, fetal calf serum was found to cause production of large amounts of immunoglobulin in without antigenic stimulation.

Item Type:Article
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Yui, Mary A.0000-0002-3136-2181
Additional Information:© 1987 Elsevier.
Issue or Number:1
Record Number:CaltechAUTHORS:20170324-082256530
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Official Citation:Stephen L. Kaattari, Mary A. Yui, Polyclonal activation of salmonid B lymphocytes, Developmental & Comparative Immunology, Volume 11, Issue 1, 1987, Pages 155-165, ISSN 0145-305X, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75373
Deposited By: Donna Wrublewski
Deposited On:24 Mar 2017 16:47
Last Modified:15 Nov 2021 16:33

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