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Echinostoma paraensei: Hemocytes of Biomphalaria glabrata as targets of echinostome mediated interference with host snail resistance to Schistosoma mansoni

Loker, Eric S. and Bayne, Christopher J. and Yui, Mary A. (1986) Echinostoma paraensei: Hemocytes of Biomphalaria glabrata as targets of echinostome mediated interference with host snail resistance to Schistosoma mansoni. Experimental Parasitology, 62 (1). pp. 149-154. ISSN 0014-4894. https://resolver.caltech.edu/CaltechAUTHORS:20170324-082803941

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Abstract

Earlier in vivo work by Lie et al. (1977) indicated that the innate resistance of the 10R2 strain of Biomphalaria glabrata to PR1 Schistosoma mansoni could be interfered with if the snails were infected previously with another trematode, Echinostoma paraensei. We have studied this interference phenomenon using in vitro methods in an attempt to understand its mechanistic basis. Hemolymph, derived from 10R2 snails infected with E. paraensei for 14–28 days, killed 25% of S. mansoni sporocysts in vitro, significantly less (P < 0.001) than the 90% killing rate observed with hemolymph from uninfected, control 10R2 snails. Hemolymph from the infected 10R2 snails and from schistosome susceptible M line snails did not differ significantly (P > 0.1) in their relative inability to kill S. mansoni sporocysts in vitro. The defect in sporocyst killing exhibited by echinostome infected 10R2 snails was traced to the cellular, rather than the humoral, component of the hemolymph. Preparations containing uninfected 10R2 snail hemolymph and echinostome daughter rediae exhibited significantly less (P < 0.001) killing of S. mansoni sporocysts than did controls containing only 10R2 hemolymph and S. mansoni sporocysts. Our results suggest that echinostome larvae release factors that interfere with the ability of B. glabrata hemocytes to kill S. mansoni sporocysts.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0014-4894(86)90018-4DOIArticle
http://www.sciencedirect.com/science/article/pii/0014489486900184PublisherArticle
ORCID:
AuthorORCID
Yui, Mary A.0000-0002-3136-2181
Additional Information:© 1986 Elsevier Inc. Accepted 2 January 1986.
Subject Keywords:Schistosoma mansoni; Echinostoma paraensei; Trematodes; Biomphalaria glabrata; Snail; Immunoparasitology; Hemolymph; Hemocytes; Interference
Issue or Number:1
Record Number:CaltechAUTHORS:20170324-082803941
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170324-082803941
Official Citation:Eric S. Loker, Christopher J. Bayne, Mary A. Yui, Echinostoma paraensei: Hemocytes of Biomphalaria glabrata as targets of echinostome mediated interference with host snail resistance to Schistosoma mansoni, Experimental Parasitology, Volume 62, Issue 1, 1986, Pages 149-154, ISSN 0014-4894, http://dx.doi.org/10.1016/0014-4894(86)90018-4. (http://www.sciencedirect.com/science/article/pii/0014489486900184)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75375
Collection:CaltechAUTHORS
Deposited By: Donna Wrublewski
Deposited On:24 Mar 2017 16:39
Last Modified:03 Oct 2019 16:49

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