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MicroRNA regulation and analytical methods in cancer cell metabolism

Zhang, Ling-Fei and Jiang, Shuai and Liu, Mo-Fang (2017) MicroRNA regulation and analytical methods in cancer cell metabolism. Cellular and Molecular Life Sciences, 74 (16). pp. 2929-2941. ISSN 1420-682X. https://resolver.caltech.edu/CaltechAUTHORS:20170324-111530553

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Abstract

The reprogramming of glucose metabolism from oxidative to glycolytic metabolism, known as the Warburg effect, is an anomalous characteristic of cancer cell metabolism. Recent studies have revealed a subset of microRNAs (miRNAs) that play critical roles in regulating the reprogramming of glucose metabolism in cancer cells. These miRNAs regulate cellular glucose metabolism by directly targeting multiple metabolic genes, including those encoding key glycolytic enzymes. In the first part of this review, we summarized the recent knowledge of miRNA regulation in the reprogramming of glucose metabolism in cancer cells and discussed the potential utilization of the key miRNA regulators as metabolic targets for developing new antitumor agents. Then, we summarized recent advances in methods and techniques for studying miRNA regulation in cancer cell metabolism.


Item Type:Article
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https://dx.doi.org/10.1007/s00018-017-2508-yDOIArticle
http://rdcu.be/qmrhPublisherFree ReadCube access
Additional Information:© 2017 Springer International Publishing. Received: 20 January 2017; Revised: 28 February 2017; Accepted: 14 March 2017; First Online: 20 March 2017. We thank other members of the Liu laboratory for discussions and comments on the manuscript. This work was supported by Grants from the National Natural Science Foundation of China (31325008, 91640201, 91419307, and 31300656), Ministry of Science and Technology of China (2014CB943103 and 2014CB964802), Science and Technology Commission of Shanghai Municipality (13ZR1464300 and 16XD1404900), and Chinese Academy of Sciences (“Strategic Priority Research Program” Grant XDB19010202). We apologize to authors whose studies have not been cited in this manuscript due to space limitations. Author contributions: All three authors were responsible for writing, reviewing, and revising the manuscript. Provenance: the authors were invited to submit this review manuscript. The authors declare that they have no conflicts of interest.
Funders:
Funding AgencyGrant Number
National Natural Science Foundation of China31325008
National Natural Science Foundation of China91640201
National Natural Science Foundation of China91419307
National Natural Science Foundation of China31300656
Ministry of Science and Technology of China2014CB943103
Ministry of Science and Technology of China2014CB964802
Science and Technology Commission of Shanghai Municipality13ZR1464300
Science and Technology Commission of Shanghai Municipality16XD1404900
Chinese Academy of SciencesXDB19010202
Subject Keywords:MicroRNAs; Reprogramming of glucose metabolism; Cancers; Analytical strategies
Issue or Number:16
Record Number:CaltechAUTHORS:20170324-111530553
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170324-111530553
Official Citation:Zhang, LF., Jiang, S. & Liu, MF. Cell. Mol. Life Sci. (2017) 74: 2929. https://doi.org/10.1007/s00018-017-2508-y
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75390
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Mar 2017 18:52
Last Modified:15 Apr 2020 22:58

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