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Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

Kollmann, Tobias R. and Kampmann, Beate and Mazmanian, Sarkis K. and Marchant, Arnaud and Levy, Ofer (2017) Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny. Immunity, 46 (3). pp. 350-363. ISSN 1074-7613. https://resolver.caltech.edu/CaltechAUTHORS:20170327-090427130

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Abstract

Infections in the first year of life are common and often severe. The newborn host demonstrates both quantitative and qualitative differences to the adult in nearly all aspects of immunity, which at least partially explain the increased susceptibility to infection. Here we discuss how differences in susceptibility to infection result not out of a state of immaturity, but rather reflect adaptation to the particular demands placed on the immune system in early life. We review the mechanisms underlying host defense in the very young, and discuss how specific developmental demands increase the risk of particular infectious diseases. In this context, we discuss how this plasticity, i.e. the capacity to adapt to demands encountered in early life, also provides the potential to leverage protection of the young against infection and disease through a number of interventions.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.immuni.2017.03.009DOIArticle
http://www.sciencedirect.com/science/article/pii/S1074761317300900PublisherArticle
ORCID:
AuthorORCID
Mazmanian, Sarkis K.0000-0003-2713-1513
Additional Information:© 2017 Elsevier Inc. Available online 21 March 2017.
Issue or Number:3
Record Number:CaltechAUTHORS:20170327-090427130
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170327-090427130
Official Citation:Tobias R. Kollmann, Beate Kampmann, Sarkis K. Mazmanian, Arnaud Marchant, Ofer Levy, Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny, Immunity, Volume 46, Issue 3, 21 March 2017, Pages 350-363, ISSN 1074-7613, http://dx.doi.org/10.1016/j.immuni.2017.03.009. (http://www.sciencedirect.com/science/article/pii/S1074761317300900)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75407
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Mar 2017 16:12
Last Modified:03 Oct 2019 16:50

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