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Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor

Willcox, Benjamin E. and Thomas, Leonard M. and Bjorkman, Pamela J. (2003) Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor. Nature Immunology, 4 (9). pp. 913-919. ISSN 1529-2908. doi:10.1038/ni961.

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Leukocyte immunoglobulin-like receptor 1 (LIR-1), an inhibitory receptor expressed on monocytes, dendritic cells and lymphocytes, regulates cellular function by binding a broad range of classical and nonclassical major histocompatibility complex (MHC) class I molecules, and the human cytomegalovirus MHC class I homolog UL18. Here we describe the 3.4-Å crystal structure of a complex between the LIR-1 D1D2 domains and the MHC class I molecule HLA-A2. LIR-1 contacts the mostly conserved β_2-microglobulin and 3 domains of HLA-A2. The LIR-1 binding site comprises residues at the interdomain hinge, and a patch at the D1 tip. The structure shows how LIR-1 recognizes UL18 and diverse MHC class I molecules, and indicates that a similar mode of MHC class I recognition is used by other LIR family members.

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Bjorkman, Pamela J.0000-0002-2277-3990
Additional Information:© 2003 Nature Publishing Group. Received 22 April; accepted 9 July 2003; published online: 3 August 2003. We thank members of the Bjorkman laboratory for technical assistance, and C. O’Callaghan and A. van der Merwe for critical reading of the manuscript. B.E.W. was supported by a Wellcome Trust Travelling Fellowship and is now funded by a Medical Research Council Career Development Award. The authors declare that they have no competing financial interests. Accession numbers: Coordinates of the structure have been deposited with the Protein Data Bank under accession code 1P7Q. Protein Data Bank accession codes: LIR-1 D1D2, 1G0X; HLA-A2, 1AKJ.
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Medical Research Council (UK)UNSPECIFIED
Issue or Number:9
Record Number:CaltechAUTHORS:20170327-140338649
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75430
Deposited By: Tony Diaz
Deposited On:27 Mar 2017 22:26
Last Modified:15 Nov 2021 16:33

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