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MHC homologs in the nervous system — they haven’t lost their groove

Olson, Rich and Dulac, Catherine and Bjorkman, Pamela J. (2006) MHC homologs in the nervous system — they haven’t lost their groove. Current Opinion in Neurobiology, 16 (3). pp. 351-357. ISSN 0959-4388. doi:10.1016/j.conb.2006.05.007.

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Major histocompatibility complex (MHC) molecules have been implicated in a number of non-immune roles in the central nervous system, particularly in synaptic development and plasticity. The discovery of M10 (50% sequence identity to classical MHC molecules) proteins expressed in the vomeronasal organ adds to the list of non-traditional roles of MHC homologs. M10 molecules associate with the V2R class of vomeronasal receptors, a family of G-protein coupled receptors thought to function as pheromone receptors. Recent studies showing that classical MHC-binding peptides activate V2R-expressing neurons offer tempting clues that M10s might participate directly in the recognition of pheromone ligands, but M10 proteins do not bind to these peptides with significant affinity. Instead of presenting MHC-binding peptides, M10s might function as molecular chaperones to V2R receptors or more generally as modulators of neuronal function, as demonstrated elsewhere in the brain for classical MHC molecules.

Item Type:Article
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Bjorkman, Pamela J.0000-0002-2277-3990
Additional Information:© 2006 Elsevier Ltd. Available online 15th May 2006. Work described in this review has in part been funded by the Howard Hughes Medical Institute (PJ Bjorkman, C Dulac) and NIH/NIDCD RO1 DC003903 (C Dulac).
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Howard Hughes Medical Institute (HHMI)UNSPECIFIED
NIHRO1 DC003903
Issue or Number:3
Record Number:CaltechAUTHORS:20170327-150740107
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Official Citation:Rich Olson, Catherine Dulac, Pamela J Bjorkman, MHC homologs in the nervous system — they haven’t lost their groove, Current Opinion in Neurobiology, Volume 16, Issue 3, June 2006, Pages 351-357, ISSN 0959-4388, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75439
Deposited By: Tony Diaz
Deposited On:27 Mar 2017 22:15
Last Modified:15 Nov 2021 16:33

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