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Structural Insights into Antibody-Mediated Mucosal Immunity

Hamburger, A. E. and Bjorkman, P. J. and Herr, A. B. (2006) Structural Insights into Antibody-Mediated Mucosal Immunity. In: Gut-Associated Lymphoid Tissues. Current Topics in Microbiology and Immunology. No.308. Springer , Berlin, pp. 173-204. ISBN 978-3-540-30656-6.

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The mucosal regions of the body are responsible for defense against environmental pathogens. Particularly in the lumen of the gut, antibody-mediated immune responses are critical for preventing invasion by pathogens. In this chapter, we review structural studies that have illuminated various aspects of mucosal immunity. Crystal structures of IgA1-Fc and IgA-binding fragments of the polymeric immunoglobulin receptor and FcαRI, combined with models of intact IgA and IgM from solution scattering studies, reveal potential mechanisms for immune exclusion and induction of inflammatory responses. Other recent structures yield insights into bacterial mechanisms for evasion of the host immune response.

Item Type:Book Section
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Bjorkman, P. J.0000-0002-2277-3990
Additional Information:© 2006 Springer Berlin Heidelberg. The authors would like to thank Dr. Steve Perkins (University College London) for providing the coordinates of pentameric IgM.
Series Name:Current Topics in Microbiology and Immunology
Issue or Number:308
Record Number:CaltechAUTHORS:20170329-110607686
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75509
Deposited By: Tony Diaz
Deposited On:29 Mar 2017 19:10
Last Modified:03 Oct 2019 16:51

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