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On the RNA synthesized during the lampbrush phase of amphibian oogenesis

Davidson, Eric H. and Allfrey, V. G. and Mirsky, A. E. (1964) On the RNA synthesized during the lampbrush phase of amphibian oogenesis. Proceedings of the National Academy of Sciences of the United States of America, 52 (2). pp. 501-508. ISSN 0027-8424. PMCID PMC300305. doi:10.1073/pnas.52.2.501.

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Lampbrush chromosomes have been observed in the growing oocytes of animals ranging from mollusks to mammals. They are present throughout the diplotene of the first meiotic division. These elongate, paired structures bear many thousands of loops projecting laterally from the main chromosomal axis, and they are characteristically accompanied in the nuclear sap by several thousand small nucleoli. It was long ago suggested that the organization of the egg and the early processes of embryogenesis were the result of nuclear activity occurring during ovarian oogenesis,(1) and we now know the lampbrush chromosomes of amphibian oocytes are in a state of intense genetic activity.

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Additional Information:© 1964 by the National Academy of Sciences. Communicated June 8, 1964. We are greatly indebted to Mrs. Judith Ann de Graaff for her expert and conscientious technical assistance. This research was supported by a grant (GM 04919-08) from the USPHS.
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)GM 04919-08
Issue or Number:2
PubMed Central ID:PMC300305
Record Number:CaltechAUTHORS:DAVpnas64
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7561
Deposited By: Tony Diaz
Deposited On:05 Mar 2007
Last Modified:01 Jun 2023 23:14

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