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Formaldehyde Ferredoxin Oxidoreductase

Roy, Roopali and Dhawan, Ish K. and Johnson, Michael K. and Rees, Douglas C. and Adams, Michael W. W. (2011) Formaldehyde Ferredoxin Oxidoreductase. In: Encyclopedia of Inorganic and Bioinorganic Chemistry. Wiley , Hoboken, NJ. ISBN 9781119951438.

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Formaldehyde ferredoxin oxidoreductase (FOR) is a homotetramer where each subunit contains a [4Fe–4S] cluster and a mononuclear tungsten atom coordinated by the dithioline groups of two pterin molecules. It is a member of a family of five closely related tungstoenzymes found in organisms that grow at high temperatures in marine volcanic vents. FOR catalyzes the two-electron oxidation of its aldehyde substrate to the corresponding acid with the concomitant reduction of ferredoxin, its physiological electron acceptor. FOR oxidizes short chain C_1-C_4 aldehydes as substrates but has the highest affinity for C_4-C_6 di- and semialdehydes. The enzyme is proposed to have a role in peptide metabolism.

Item Type:Book Section
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Rees, Douglas C.0000-0003-4073-1185
Additional Information:© 2011 John Wiley & Sons, Ltd. Published Online: 15 DEC 2011. Research on tungstoenzymes carried out in the authors' laboratories was supported by grants from the Department of Energy, the National Science Foundation and the National Institutes of Health.
Funding AgencyGrant Number
Department of Energy (DOE)UNSPECIFIED
Subject Keywords:tungsten; tungsten-containing enzyme; formaldehyde oxidoreductase; iron-sulfur cluster; pterin cofactor; pyrococcus furiosus; thermococcus litoralis; semialdehyde oxidation; hyperthermophile; ferredoxin
Record Number:CaltechAUTHORS:20170403-151722541
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Official Citation:Roy, R., Dhawan, I. K., Johnson, M. K., Rees, D. C. and Adams, M. W. 2011. Formaldehyde Ferredoxin Oxidoreductase. Encyclopedia of Inorganic and Bioinorganic Chemistry
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75652
Deposited By: Tony Diaz
Deposited On:03 Apr 2017 22:25
Last Modified:03 Oct 2019 16:52

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