Roy, Roopali and Dhawan, Ish K. and Johnson, Michael K. and Rees, Douglas C. and Adams, Michael W. W. (2011) Aldehyde Ferredoxin Oxidoreductase. In: Encyclopedia of Inorganic and Bioinorganic Chemistry. Wiley , Hoboken, NJ. ISBN 9781119951438. https://resolver.caltech.edu/CaltechAUTHORS:20170403-152926110
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Abstract
Aldehyde ferredoxin oxidoreductase (AOR) is a homodimer where each subunit contains a [4Fe–4S] cluster and a mononuclear tungsten atom coordinated by the dithioline groups of two pterin molecules. The two subunits of the dimer are bridged by a monomeric iron site. AOR is a member of a family of five closely related tungstoenzymes found in organisms that grow at high temperatures in marine volcanic vents. The enzyme catalyzes the two-electron oxidation of its aldehyde substrate to the corresponding acid with the concomitant reduction of ferredoxin, its physiological electron acceptor. The enzyme can oxidize a wide range of aliphatic and aromatic aldehydes. The most efficient substrates for AOR are acetaldehyde, isovaleraldehyde, phenylacetaldehyde, and indoleacetaldehyde, the aldehyde derivatives of some of the most common amino acids.
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| Additional Information: | © 2011 John Wiley & Sons, Ltd. Published Online: 15 DEC 2011. Research on tungstoenzymes carried out in the authors' laboratories was supported by grants from the Department of Energy, the National Science Foundation and the National Institutes of Health. | |||||||||
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| Subject Keywords: | tungsten; tungsten-containing enzyme; pterin cofactor; iron-sulfur cluster; aldehyde oxidoreductase; ferredoxin; pyrococcus furiosus; hyperthermophile | |||||||||
| Record Number: | CaltechAUTHORS:20170403-152926110 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20170403-152926110 | |||||||||
| Official Citation: | Roy, R., Dhawan, I. K., Johnson, M. K., Rees, D. C. and Adams, M. W. 2011. Aldehyde Ferredoxin Oxidoreductase. Encyclopedia of Inorganic and Bioinorganic Chemistry | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 75653 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 03 Apr 2017 22:39 | |||||||||
| Last Modified: | 03 Oct 2019 16:52 |
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