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Aldehyde Ferredoxin Oxidoreductase

Roy, Roopali and Dhawan, Ish K. and Johnson, Michael K. and Rees, Douglas C. and Adams, Michael W. W. (2011) Aldehyde Ferredoxin Oxidoreductase. In: Encyclopedia of Inorganic and Bioinorganic Chemistry. Wiley , Hoboken, NJ. ISBN 9781119951438.

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Aldehyde ferredoxin oxidoreductase (AOR) is a homodimer where each subunit contains a [4Fe–4S] cluster and a mononuclear tungsten atom coordinated by the dithioline groups of two pterin molecules. The two subunits of the dimer are bridged by a monomeric iron site. AOR is a member of a family of five closely related tungstoenzymes found in organisms that grow at high temperatures in marine volcanic vents. The enzyme catalyzes the two-electron oxidation of its aldehyde substrate to the corresponding acid with the concomitant reduction of ferredoxin, its physiological electron acceptor. The enzyme can oxidize a wide range of aliphatic and aromatic aldehydes. The most efficient substrates for AOR are acetaldehyde, isovaleraldehyde, phenylacetaldehyde, and indoleacetaldehyde, the aldehyde derivatives of some of the most common amino acids.

Item Type:Book Section
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Rees, Douglas C.0000-0003-4073-1185
Additional Information:© 2011 John Wiley & Sons, Ltd. Published Online: 15 DEC 2011. Research on tungstoenzymes carried out in the authors' laboratories was supported by grants from the Department of Energy, the National Science Foundation and the National Institutes of Health.
Funding AgencyGrant Number
Department of Energy (DOE)UNSPECIFIED
Subject Keywords:tungsten; tungsten-containing enzyme; pterin cofactor; iron-sulfur cluster; aldehyde oxidoreductase; ferredoxin; pyrococcus furiosus; hyperthermophile
Record Number:CaltechAUTHORS:20170403-152926110
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Official Citation:Roy, R., Dhawan, I. K., Johnson, M. K., Rees, D. C. and Adams, M. W. 2011. Aldehyde Ferredoxin Oxidoreductase. Encyclopedia of Inorganic and Bioinorganic Chemistry
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75653
Deposited By: Tony Diaz
Deposited On:03 Apr 2017 22:39
Last Modified:03 Oct 2019 16:52

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