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Selection of Pharmaceutical Antioxidants by Hydrodynamic Voltammetry

Webster, Gregory K. and Craig, Robert A., II and Pommerening, Cynthia A. and Acworth, Ian N. (2012) Selection of Pharmaceutical Antioxidants by Hydrodynamic Voltammetry. Electroanalysis, 24 (6). pp. 1394-1400. ISSN 1521-4109. https://resolver.caltech.edu/CaltechAUTHORS:20170404-082006891

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Abstract

Antioxidant compounds are routinely included in pharmaceutical formulations in order to minimize the oxidative degradation of the active pharmaceutical ingredient(s) (API). The effectiveness of the antioxidants being considered is often assessed by creating several formulations with the API(s) and single or multiple antioxidants in order to place each of these formulations on stability under accelerated conditions. This trial and error selection process is costly and time consuming, often taking weeks before the oxidation is observed at a detectable level. Using a flow injection coulometric detector based system, a potential tool has been developed to guide initial antioxidant selection for hindering the oxidative degradation for a given drug substance in its formulation environment. The relative potential for the API to be oxidized can be measured by matching the conditions of the coulometric experiment to the formulation matrix. Using this selection criterion, the choice of antioxidants to study for individual formations can be greatly narrowed, thus leading to a significant savings in development time and cost.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/elan.201200071DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/elan.201200071/abstractPublisherArticle
Additional Information:© 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Issue online: 4 June 2012; Version of record online: 9 May 2012; Manuscript Accepted: 7 April 2012; Manuscript Received: 2 February 2012.
Subject Keywords:Hydrodynamic voltammetry; Pharmaceutical antioxidants; Drug oxidation
Issue or Number:6
Record Number:CaltechAUTHORS:20170404-082006891
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170404-082006891
Official Citation:Webster, G. K., Craig, R. A., Pommerening, C. A. and Acworth, I. N. (2012), Selection of Pharmaceutical Antioxidants by Hydrodynamic Voltammetry. Electroanalysis, 24: 1394–1400. doi:10.1002/elan.201200071
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75669
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Apr 2017 19:18
Last Modified:03 Oct 2019 16:52

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