A Caltech Library Service

Variations in DNA Charge Transport with Nucleotide Composition and Sequence

Williams, Tashica T. and Odom, Duncan T. and Barton, Jacqueline K. (2000) Variations in DNA Charge Transport with Nucleotide Composition and Sequence. Journal of the American Chemical Society, 122 (37). pp. 9048-9049. ISSN 0002-7863. doi:10.1021/ja001552k.

[img] PDF - Supplemental Material
See Usage Policy.


Use this Persistent URL to link to this item:


Long-range oxidative damage to DNA has been demonstrated in experiments using a variety of remotely bound oxidants. However, the mechanism(s) by which charge is transported through the base pair stack needs still to be established. Recent theoretical proposals bring together tunneling and hopping mechanisms to describe charge transport. On the basis of measurements of damage yield, it has been proposed that charge transport occurs by hopping between guanine sites and tunneling through TA steps. In accord with guanine hopping, oxidative damage over long distances was not observed when 5‘-TATATA-3‘ intervened between G sites. Phonon-assisted polaron hopping has been suggested as an alternative mechanism. In this model, the sequence-dependent conformational dynamics of DNA are expected to aid in charge transport.

Item Type:Article
Related URLs:
URLURL TypeDescription ItemSupporting Information
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2000 American Chemical Society. Received 5 May 2000. Published online 30 August 2000. Published in print 1 September 2000. We are grateful to the NIH for financial support (GM49216). We also thank the NSF for a predoctoral fellowship for T.T.W. and the NRSA for a predoctoral training grant to D.T.O.
Funding AgencyGrant Number
NIH Predoctoral FellowshipUNSPECIFIED
Issue or Number:37
Record Number:CaltechAUTHORS:20170404-082323148
Persistent URL:
Official Citation:Variations in DNA Charge Transport with Nucleotide Composition and Sequence Tashica T. Williams, Duncan T. Odom, and Jacqueline K. Barton Journal of the American Chemical Society 2000 122 (37), 9048-9049 DOI: 10.1021/ja001552k
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75670
Deposited By: Ruth Sustaita
Deposited On:04 Apr 2017 19:16
Last Modified:15 Nov 2021 16:35

Repository Staff Only: item control page