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Fast and Slow Contrast Adaptation in Retinal Circuitry

Baccus, Stephen A. and Meister, Markus (2002) Fast and Slow Contrast Adaptation in Retinal Circuitry. Neuron, 36 (5). pp. 909-919. ISSN 0896-6273. doi:10.1016/S0896-6273(02)01050-4. https://resolver.caltech.edu/CaltechAUTHORS:20170404-131413153

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Abstract

The visual system adapts to the magnitude of intensity fluctuations, and this process begins in the retina. Following the switch from a low-contrast environment to one of high contrast, ganglion cell sensitivity declines in two distinct phases: a fast change occurs in <0.1 s, and a slow decrease over ∼10 s. To examine where these modulations arise, we recorded intracellularly from every major cell type in the salamander retina. Certain bipolar and amacrine cells, and all ganglion cells, adapted to contrast. Generally, these neurons showed both fast and slow adaptation. Fast effects of a contrast increase included accelerated kinetics, decreased sensitivity, and a depolarization of the baseline membrane potential. Slow adaptation did not affect kinetics, but produced a gradual hyperpolarization. This hyperpolarization can account for slow adaptation in the spiking output of ganglion cells.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0896-6273(02)01050-4DOIArticle
http://www.sciencedirect.com/science/article/pii/S0896627302010504PublisherArticle
ORCID:
AuthorORCID
Meister, Markus0000-0003-2136-6506
Additional Information:© 2002 Cell Press. Received 12 June 2002, Revised 8 October 2002, Available online 10 December 2002. We thank the members of our laboratory for insightful discussions, and Ed Soucy and Tim Holy for important technical contributions. S.A.B. was supported by an NRSA from NEI, and M.M. by a grant from NEI.
Funders:
Funding AgencyGrant Number
NIH Predoctoral FellowshipUNSPECIFIED
National Eye InstituteUNSPECIFIED
Issue or Number:5
DOI:10.1016/S0896-6273(02)01050-4
Record Number:CaltechAUTHORS:20170404-131413153
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170404-131413153
Official Citation:Stephen A. Baccus, Markus Meister, Fast and Slow Contrast Adaptation in Retinal Circuitry, Neuron, Volume 36, Issue 5, 5 December 2002, Pages 909-919, ISSN 0896-6273, http://dx.doi.org/10.1016/S0896-6273(02)01050-4. (http://www.sciencedirect.com/science/article/pii/S0896627302010504)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75696
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Apr 2017 21:41
Last Modified:15 Nov 2021 16:35

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