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Modeling convergent ON and OFF pathways in the early visual system

Gollisch, Tim and Meister, Markus (2008) Modeling convergent ON and OFF pathways in the early visual system. Biological Cybernetics, 99 (4-5). pp. 263-278. ISSN 0340-1200. PMCID PMC2784078. doi:10.1007/s00422-008-0252-y.

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For understanding the computation and function of single neurons in sensory systems, one needs to investigate how sensory stimuli are related to a neuron’s response and which biological mechanisms underlie this relationship. Mathematical models of the stimulus–response relationship have proved very useful in approaching these issues in a systematic, quantitative way. A starting point for many such analyses has been provided by phenomenological “linear–nonlinear” (LN) models, which comprise a linear filter followed by a static nonlinear transformation. The linear filter is often associated with the neuron’s receptive field. However, the structure of the receptive field is generally a result of inputs from many presynaptic neurons, which may form parallel signal processing pathways. In the retina, for example, certain ganglion cells receive excitatory inputs from ON-type as well as OFF-type bipolar cells. Recent experiments have shown that the convergence of these pathways leads to intriguing response characteristics that cannot be captured by a single linear filter. One approach to adjust the LN model to the biological circuit structure is to use multiple parallel filters that capture ON and OFF bipolar inputs. Here, we review these new developments in modeling neuronal responses in the early visual system and provide details about one particular technique for obtaining the required sets of parallel filters from experimental data.

Item Type:Article
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Meister, Markus0000-0003-2136-6506
Additional Information:© 2008 The Author(s). This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. Received: 19 February 2008 / Accepted: 25 August 2008. First Online: 15 November 2008. This work was supported by grants from the National Eye Institute (M.M.) and the Human Frontier Science Program Organization (T.G.) and by the Max Planck Society.
Funding AgencyGrant Number
National Eye InstituteUNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Max Planck SocietyUNSPECIFIED
Subject Keywords:LN model extension; Multiple pathways; Spike-triggered analysis; Retina ON–OFF ganglion cells
Issue or Number:4-5
PubMed Central ID:PMC2784078
Record Number:CaltechAUTHORS:20170404-143539566
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Official Citation:Gollisch, T. & Meister, M. Biol Cybern (2008) 99: 263. doi:10.1007/s00422-008-0252-y
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75703
Deposited By: Tony Diaz
Deposited On:04 Apr 2017 21:44
Last Modified:15 Nov 2021 16:35

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